Nutritional Deficiency in Early Life Facilitates Aging-Associated Cognitive Decline

被引：41

作者：

Kang, Yu ^{[1
,2
]}

Zhang, Yun ^{[3
]}

Feng, Zijuan ^{[1
,2
]}

Liu, Mingjing ^{[1
,2
]}

Li, Yanhua ^{[1
,2
]}

Yang, Huan ^{[1
,2
]}

Wang, Dan ^{[1
,2
]}

Zheng, Lingling ^{[1
,2
]}

Lou, Dandan ^{[1
,2
]}

Cheng, Liangping ^{[1
,2
]}

Chen, Chunjiang ^{[1
,2
]}

Zhou, Weitao ^{[1
,2
]}

Feng, Yi ^{[1
,2
]}

Li, Xiaoyong ^{[1
,2
]}

Duan, Jianzhong ^{[1
,2
]}

Yu, Mengjiao ^{[1
,2
]}

Yang, Shou ^{[1
,2
]}

Liu, Yuhang ^{[1
,2
]}

Wang, Xin ^{[4
]}

Deng, Bo ^{[4
]}

Liu, Chenghui ^{[4
]}

Yao, Xiuqing ^{[4
]}

Zhu, Chi ^{[4
]}

Liang, Chunrong ^{[4
]}

Zeng, Xiaolong ^{[5
]}

Ren, Sisi ^{[5
]}

Li, Qunying ^{[5
]}

Zhong, Yin ^{[5
]}

Zhang, Yong ^{[5
]}

Kang, Jun ^{[5
]}

Yan, Yong ^{[6
]}

Meng, Huaqing ^{[7
]}

Zhong, Zhaohui ^{[5
]}

Zhou, Weihui ^{[1
,2
]}

Wang, Yanjiang ^{[4
]}

Li, Tingyu ^{[1
,2
]}

Song, Weihong ^{[1
,2
,3
]}

机构：

[1] Chongqing Med Univ, Childrens Hosp,Pediat Res Inst, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing City Key Lab Translat Med Res Cognit De, Chongqing 400014, Peoples R China

[2] Chongqing Med Univ, Childrens Hosp,Pediat Res Inst, China Int Sci & Technol Cooperat Base Child Dev &, Minist Educ,Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China

[3] Univ British Columbia, Townsend Family Labs, Dept Psychiat, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada

[4] Third Mil Med Univ, Daping Hosp, Dept Neurol, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China

[5] Chongqing Med Univ, Sch Publ Hlth & Management, Epidemiol Res Inst, Chongqing 400016, Peoples R China

[6] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China

[7] Chongqing Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, 1 Youyi Rd, Chongqing 400016, Peoples R China

来源：

CURRENT ALZHEIMER RESEARCH | 2017年 / 14卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Famine; malnutrition; early life; risk factor; mild cognitive impairment; dementia; PRENATAL PROTEIN-MALNUTRITION; MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; DNA METHYLATION; DIABETES-MELLITUS; FAMINE EXPOSURE; CHINESE FAMINE; DEMENTIA; ADULTHOOD; RISK;

D O I：

10.2174/1567205014666170425112331

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline. Objective: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. Methods: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961). Cognitive function of these subjects were evaluated using the Mini-Mental State Examination (MMSE), the Activities of Daily Living scale (ADL), the Instrumental Activities of Daily Living scale (IADL) and the Clinical Dementia Rating (CDR). Results: Our study identified that early exposure to the famine significantly increased the risk of cognitive impairments in later life, leading to higher prevalence of Mild Cognitive Impairment (MCI) and dementia. We also found the sex and rural-urban differences in this malnutrition-induced effect. Illiteracy, history of stroke or diabetes mellitus are great risk factors to facilitate the cognitive decline. Conclusion: These findings demonstrate that exposure to famine during early life including prenatal period and early childhood facilitates aging-associated cognitive deficits.

引用

页码：841 / 849

页数：9

共 52 条

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