Human protein C concentrate in pediatric septic patients

被引：1

作者：

Landoni, Giovanni ^{[1
]}

Monti, Giacomo ^{[1
]}

Facchini, Alberto ^{[1
]}

Cama, Francesco ^{[1
]}

Bignami, Elena ^{[1
]}

Cabrini, Luca ^{[1
]}

Pappalardo, Federico ^{[1
]}

Zangrillo, Alberto ^{[1
]}

机构：

[1] Univ Vita Salute San Raffaele Milano, Dept Anesthesia & Intens Care, Milan, Italy

来源：

SIGNA VITAE | 2010年 / 5卷 / 01期

关键词：

sepsis; pediatric; protein C; drug therapy; review; PURPURA FULMINANS; SEVERE SEPSIS; MENINGOCOCCAL SEPTICEMIA; REPLACEMENT THERAPY; ACTIVATION; CHILDREN; MORTALITY; NEONATE; SYSTEM;

D O I：

10.22514/SV51.042010.2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Severe sepsis and septic shock are leading causes of morbidity and mortality in the pediatric population. Unlike what is suggested for the adult population, recombinant human activated protein C (rhAPC) is contraindicated in children. Long before rhAPC was considered for use in pediatric patients, case reports appeared on the safe administration of protein C zymogen. Therefore, we conducted a systemic review of currently available data on protein C zymogen (PC) use among children affected by severe sepsis or septic shock. A total number of 13 case series or case reports and a dose-finding study were found on the use of PC in the pediatric intensive care unit, reporting on 118 treated children, with an overall survival of 84%. There was no bleeding complication, the only reported complication being a single mild allergic reaction. These studies show that PC is safe, not associated with bleeding and possibly useful for improving coagulation abnormalities of sepsis.

引用

页码：13 / 19

页数：7

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