Protein-protein interactions mapped by artificial proteases:: where σ factors bind to RNA polymerase

被引：42

作者：

Datwyler, SA ^{[1
]}

Meares, CF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(00)01652-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions between proteins are important to understand but difficult to study. Conjugating a protein to a small artificial protease endows it with the ability to cut other proteins where it binds to them. Analysing the sites cut on the target proteins leads to new understanding of the structure of each complex. The binding of a factors to a common region on RNA polymerase provides an example.

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页码：408 / 414

页数：7

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