Ultrabroad Bandwidth and Highly Sensitive Optical Ultrasonic Detector for Photoacoustic Imaging

被引:119
作者
Zhang, Cheng [1 ]
Ling, Tao [1 ]
Chen, Sung-Liang [1 ]
Guo, L. Jay [1 ]
机构
[1] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA
基金
美国国家科学基金会;
关键词
broadband ultrasound detector; microring resonator; photoacoustic imaging; axial resolution; IN-VIVO; MICROSCOPY; TOMOGRAPHY; TRANSDUCERS; ABSORPTION; RADIATION; SENSOR;
D O I
10.1021/ph500159g
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
We demonstrate an ultrasonic detector with unprecedented broad bandwidth and high sensitivity, based on an imprinted polymer optical microring. It has an acoustic response of up to 350 MHz at -3 dB and noise-limited detectable pressure as low as 105 Pa in this frequency range. Application of such a detector in photoacoustic imaging leads to improved axial resolving ability compared with using the conventional ultrasound detector, and sub-3 mu m axial resolution is achieved, which is more than a 2-fold improvement with respect to the reported record. The device's miniaturized cavity height guarantees its broadband response, and at the same time, its high optical quality factor ensures the detection sensitivity. Our work suggests that the polymer-based miniature microring resonator works as a high-performance ultrasound detector and has potential for acquiring volumetric photoacoustic images with cellular/subcellular resolution in three dimensions.
引用
收藏
页码:1093 / 1098
页数:6
相关论文
共 38 条
[1]   Ultra-high-Q toroid microcavity on a chip [J].
Armani, DK ;
Kippenberg, TJ ;
Spillane, SM ;
Vahala, KJ .
NATURE, 2003, 421 (6926) :925-928
[2]   Laser ultrasonic inspection of the microstructural state of thin metal foils [J].
Balogun, O. ;
Huber, R. ;
Chinn, D. ;
Spicer, J. B. .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2009, 125 (03) :1437-1443
[3]   Transduction mechanisms of the Fabry-Perot polymer film sensing concept for wideband ultrasound detection [J].
Beard, PC ;
Pérennès, F ;
Mills, TN .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 1999, 46 (06) :1575-1582
[4]  
Chen SL, 2014, NAT PHOTONICS, V8, P537, DOI [10.1038/NPHOTON.2014.96, 10.1038/nphoton.2014.96]
[5]   Low-noise small-size microring ultrasonic detectors for high-resolution photoacoustic imaging [J].
Chen, Sung-Liang ;
Ling, Tao ;
Guo, L. Jay .
JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (05)
[6]   Polymer Microring Resonators for High-Sensitivity and Wideband Photoacoustic Imaging [J].
Chen, Sung-Liang ;
Huang, Sheng-Wen ;
Ling, Tao ;
Ashkenazi, Shai ;
Guo, L. Jay .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2009, 56 (11) :2482-2491
[7]   Two-dimensional arrays for medical ultrasound using multilayer flexible circuit interconnection [J].
Davidsen, RE ;
Smith, SW .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 1998, 45 (02) :338-348
[8]   PHOTOACOUSTIC MONOPOLE RADIATION IN 1-DIMENSION, 2-DIMENSION, AND 3-DIMENSION [J].
DIEBOLD, GJ ;
SUN, T ;
KHAN, MI .
PHYSICAL REVIEW LETTERS, 1991, 67 (24) :3384-3387
[9]   A history of medical and biological imaging with polyvinylidene fluoride (PVDF) transducers [J].
Foster, FS ;
Harasiewicz, EA ;
Sherar, MD .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2000, 47 (06) :1363-1371
[10]   Ultra-wideband three-dimensional optoacoustic tomography [J].
Gateau, Jerome ;
Chekkoury, Andrei ;
Ntziachristos, Vasilis .
OPTICS LETTERS, 2013, 38 (22) :4671-4674