Effect of recombinant basic fibroblast growth factor (bFGF) on fibroblast-like cells from human rotator cuff tendon

被引：33

作者：

Takahashi, S ^{[1
]}

Nakajima, M ^{[1
]}

Kobayashi, M ^{[1
]}

Wakabayashi, I ^{[1
]}

Miyakoshi, N ^{[1
]}

Minagawa, H ^{[1
]}

Itoi, E ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Orthoped Surg, Akita 0108543, Japan

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 2002年 / 198卷 / 04期

关键词：

basic fibroblast growth factor; rotator cuff tendon; collagen; proliferation; primary culture;

D O I：

10.1620/tjem.198.207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rotator cuff tendon cells (RCC) derived from surgical samples showed fibroblast-like morphology. Histological staining demonstrated collagen secretion by RCC. Immunohistological findings revealed that RCC secreted type I and III collagen, but not type II collagen. In addition, the SDS-PAGE analysis suggested that RCC predominantly produced type I collagen. Basic fibroblast growth factor (bFGF) had a stimulatory effect on the proliferation of RCC dose-dependently up to 1 ng/ml. Administration of bFGF suppressed the secretion of collagens from RCC in a dose-dependent manner. - basic fibroblast growth factor; rotator cuff tendon; collagen; proliferation; primary culture (C) 2002 Tohoku University Medical Press.

引用

页码：207 / 214

页数：8

共 14 条

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