Role of basophils in the initiation of Th2 responses

被引：65
作者：
Sokol, Caroline L. [1 ]
Medzhitov, Ruslan [2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Internal Med, Boston, MA 02114 USA
[2] Yale Univ, Sch Med, Dept Immunobiol, Howard Hughes Med Inst, New Haven, CT 06510 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 01期
关键词：
HUMAN IGE SYNTHESIS; ANTIGEN-PRESENTING CELLS; CD4(+) T-CELLS; IL-4; PRODUCTION; IN-VIVO; B-CELLS; HELMINTH INFECTION; TYPE-2; IMMUNITY; MOUSE BASOPHIL; CUTTING EDGE;
D O I：
10.1016/j.coi.2010.01.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Long appreciated for their role as Type-2 effector cells, basophils have recently come into the spotlight for their role in the initiation of Type-2 immunity. Via an assortment of different activation pathways, basophils produce cytokines such as IL-4 that promote Th2 differentiation. Furthermore, recent studies using different experimental systems have shown that basophils can act as antigen presenting cells both in vitro and in vivo. In addition, basophils shape the Type-2 immune response by guiding antibody production and the memory response.
引用
收藏
页码：73 / 77
页数：5
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