Planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes via palladium(0)-catalyzed C-H functionalization of trifluoroacetimidoyl chlorides

被引：25

作者：

Zhang, An-An ^{[1
]}

Chen, Chao ^{[1
]}

Gao, Yushen ^{[1
]}

Mo, Mingyang ^{[1
]}

Shen, Ren-Zeng ^{[1
]}

Zhang, Yu-Heng ^{[1
]}

Ishida, Naoki ^{[2
]}

Murakami, Masahiro ^{[2
]}

Liu, Lantao ^{[1
,3
,4
]}

机构：

[1] Shangqiu Normal Univ, Coll Chem & Chem Engn, Henan Engn Lab Green Synth Pharmaceut, Shangqiu 476000, Peoples R China

[2] Kyoto Univ, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan

[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

[4] Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100871, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2021年 / 2卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Planar -chiral ferrocenes; Palladium; C -H functionalization; 2-(Trifluoromethyl)quinolines; Trifluoroacetimidoyl chlorides; ENANTIOSELECTIVE SYNTHESIS; BOND FUNCTIONALIZATION; RADICAL TRIFLUOROMETHYLATION; ASYMMETRIC CATALYSIS; COUPLING REACTION; ISOCYANIDES; ARYLATION; LIGANDS; FLUOROALKYLATION; CYCLOADDITION;

D O I：

10.1016/j.gresc.2021.05.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic enantioselective synthesis of planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes has been achieved through Pd(0)-catalyzed C-H functionalization with trifluoroacetimidoyl chlorides as electrophilics. With commercially available ligand and palladium precursor, the reaction proceeds smoothly generating 2-perfluoroalkylated quinoline-fused ferrocenes in high yields and enantioselectivities.

引用

页码：311 / 314

页数：4

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