Reductive Umpolung Reactions with Low-Valent Titanium Catalysts

被引：50
作者：
Streuff, Jan [1 ]
机构：
[1] Univ Freiburg, Inst Organ Chem, D-79104 Freiburg, Germany
来源：
CHEMICAL RECORD | 2014年 / 14卷 / 06期
关键词：
homogeneous catalysis; radical reactions; reduction; titanium; umpolung; QUATERNARY STEREOGENIC CENTERS; PINACOL COUPLING REACTION; CONJUGATE ADDITION; ELECTRON-TRANSFER; RADICAL CYCLIZATION; ARYL HALIDES; ACTIVATED ALKENES; ALKYL-HALIDES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC 1,4-ADDITION;
D O I：
10.1002/tcr.201402058
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The coupling of similarly polarized carbon fragments can be achieved by a reductive umpolung strategy. This gives access to compounds with functional groups in even bond distances, which are difficult to synthesize by other means. Low-valent titanium catalysts enable such couplings under mild conditions. This account covers the recent progress on this topic with a focus on the development of cross-selective coupling reactions and stereoselective examples.
引用
收藏
页码：1100 / 1113
页数：14
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