Facile preparation of protected furanoid glycals from thymidine

被引：62

作者：

Cameron, MA ^{[1
]}

Cush, SB ^{[1
]}

Hammer, RP ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 26期

关键词：

D O I：

10.1021/jo970947s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of O-silyl- and O-acyl-protected furanose glycals from free thymidine was investigated. The method of glycal formation reported by Pedersen et al. was successfully expanded to include 5-ester (toluoyl) protected glycals as well as various combinations of 5'-ester and 3- and 5-tert-butyldimethylsilyl and tert-butyldiphenylsilyl protection. Gram quantities of furanoid glycals can be prepared in a few days in two-four synthetic steps in overall yields ranging from 17 to 80%.

引用

页码：9065 / 9069

页数：5

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