Airway compliance measured by anatomic optical coherence tomography

被引：11

作者：

Bu, Ruofei ^{[1
]}

Balakrishnan, Santosh ^{[1
]}

Iftimia, Nicusor ^{[2
]}

Price, Hillel ^{[3
]}

Zdanski, Carlton ^{[4
]}

Oldenburg, Amy L. ^{[1
,3
,5
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Biomed Engn, Chapel Hill, NC 27599 USA

[2] Phys Sci Inc, New England Business Ctr, Andover, MA 01810 USA

[3] Univ North Carolina Chapel Hill, Dept Phys & Astron, Chapel Hill, NC 27599 USA

[4] Univ North Carolina Chapel Hill, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA

[5] Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr, Chapel Hill, NC 27514 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2017年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

OBSTRUCTIVE SLEEP-APNEA; ROTATIONAL DISTORTION; SWEPT-SOURCE; IN-VIVO; SIZE; INDIVIDUALS; CHILDREN; SHAPE;

D O I：

10.1364/BOE.8.002195

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal crosssectional area (CSA) under physiologically relevant pressures of 10-40 cmH(2)O. The accuracy and precision of CC measurements are determined using simulations of non-uniform rotation distortion (NURD) endemic to endoscopic scanning, and experiments performed in a simplified tube phantom and ex vivo porcine tracheas. NURD simulations show that CC measurements are typically more accurate than that of the CSAs from which they are derived. Phantom measurements of CSA versus pressure exhibit high linearity (R-2>0.99), validating the dynamic range of the SSaOCT system. Tracheas also exhibited high linearity (R-2 = 0.98) suggestive of linear elasticity, while CC measurements were obtained with typically +/- 12% standard error. (C) 2017 Optical Society of America

引用

页码：2195 / 2209

页数：15

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