Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol

被引：0

作者：

Munira, Rubina ^{[1
,2
]}

Athar, Muhammad Makshoof ^{[1
]}

Zia-ur-Rehman, Muhammad ^{[3
]}

Javid, Noman ^{[1
,4
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[2] Kinnaird Coll Women, Dept Chem, 93 Jail Rd, Lahore 54000, Pakistan

[3] Appl Chem Res Ctr, PCSIR Labs Complex, Lahore 54600, Pakistan

[4] Forman Christian Coll, Chem Dept, C Block,Ferozepur Rd, Lahore, Pakistan

来源：

CHIANG MAI JOURNAL OF SCIENCE | 2020年 / 47卷 / 01期

关键词：

quinoline; nucleophilic aromatic substitution; phase transfer catalyst; CTAB; piperidine; QUINOLINES; DERIVATIVES; ANTICANCER; DESIGN;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.

引用

页码：175 / 180

页数：6

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