AgBiS2 nanoparticles with synergistic photodynamic and bioimaging properties for enhanced malignant tumor phototherapy

被引：49

作者：

Cheng, Jing ^{[1
]}

Wang, Wanshun ^{[2
]}

Xu, Xingyi ^{[3
]}

Lin, Zefeng ^{[2
]}

Xie, Chao ^{[1
]}

Zhang, Yuxuan ^{[1
]}

Zhang, Tao ^{[2
]}

Li, Lihua ^{[3
]}

Lu, Yao ^{[1
,2
,4
]}

Li, Qi ^{[1
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Dept Orthoped, 253 Gongye Rd, Guangzhou 510282, Guangdong, Peoples R China

[2] Gen Hosp Southern Theater Command PLA, Hosp Orthoped, Key Lab Trauma & Tissue Repair Trop Area PLA, Guangdong Key Lab Orthoped Technol & Implant Mat, 111 Liuhua Rd, Guangzhou 510010, Guangdong, Peoples R China

[3] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Prov Key Lab Fiber Laser Mat, Sch Mat Sci & Engn,Sch Phys, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

[4] Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, 253 Gongye Rd, Guangzhou 510282, Guangdong, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 107卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

GOLD NANOPARTICLES; CARBON DOTS; THERAPY; CANCER; NANOCRYSTALS; INFLAMMATION; SILVER;

D O I：

10.1016/j.msec.2019.110324

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Bismuth (Bi)-based nanoagents for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) are attracting attention and are highly desired for malignant tumor diagnosis and treatment, but producing these materials is still a challenge. Here, we designed theranostic nanoparticles (NPs) based on AgBiS2 for computed tomography (CT) imaging and phototherapy of malignant tumors. These AgBiS2 NPs could effectively convert light into heat (with a high photothermal conversion efficiency of 36.51%) and significantly increase the generation of intracellular reactive oxygen species (ROS) under near infrared (NIR) laser irradiation. Remarkably, the combined PTT/PDT successfully inhibited the growth of a highly malignant osteosarcoma in vivo. In addition, AgBiS2 NPs exhibited an enhanced CT contrast ability for tumor imaging and killed clinically derived Staphylococcus aureus (S. aureus) to prevent infection. In conclusion the ability of AgBiS2 NPs to be used in phototherapy and CT imaging and their antibacterial abilities indicate that they are promising candidates for malignant tumor theranostics.

引用

页数：9

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