Enantioselective synthesis of cadinanes starting from R-(-)-or S-(+)-carvone

被引：10

作者：

Baranovsky, AV

Jansen, BJM

Meulemans, TM

de Groot, A

机构：

[1] Agr Univ Wageningen, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

[2] Byelarussian Acad Sci, Inst Bioorgan Chem, Lab Steroid Chem, Minsk 220141, BELARUS

来源：

TETRAHEDRON | 1998年 / 54卷 / 21期

关键词：

D O I：

10.1016/S0040-4020(98)00234-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new enantioselective synthesis of cadinanes, using the Mukaiyama-Michael reaction, was developed starting from R-(-)- or S-(+)-carvone. This approach gives an easy and direct access to the cadinane skeleton and the scope proved to be complementary to a formylation-annelation sequence. The applicability of the method was demonstrated by the enantioselective synthesis of 1,9-cadinadien-3-one and 4-methoxy-1,9-cadinadien-3-one. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5623 / 5634

页数：12

共 20 条

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