Glucocorticoids: A Doping Agent?

被引:37
作者
Duclos, Martine [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Hosp CHU, Hop G Montpied, Dept Sport Med & Funct Explorat, F-63003 Clermont Ferrand, France
[2] INRA, UMR 1019, F-63009 Clermont Ferrand, France
[3] Univ Clermont 1, UFR Med, F-63009 Clermont Ferrand, France
[4] Ctr Rech Nutr Humaine Auvergne, F-63009 Clermont Ferrand, France
[5] CHU Hop G Montpied, Serv Med Sport & Explorat Fonct, F-63009 Clermont Ferrand 1, France
关键词
Glucocorticoids; Exercise; Performance; Doping; Adrenal insufficiency; Adverse effects; ACUTE PREDNISOLONE INTAKE; SHORT-TERM; SKELETAL-MUSCLE; CORTISOL; DEXAMETHASONE; EXERCISE; INSUFFICIENCY; SENSITIVITY; SUPPRESSION; METABOLISM;
D O I
10.1016/j.ecl.2009.10.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Certain international sports federations are requesting that glucocorticoids (GCs) be removed from the World Antidoping Agency's list of banned products. Their arguments are based on the fact that GCs are in widespread use in sports medicine and have no demonstrated ergogenic activity. This article shows that there is scientific evidence that GCs mediate ergogenic effects in animals and humans. Moreover, the health risks of using GCs are well characterized. GCs are doping agents and should remain on the World Antidoping Agency's list of banned products.
引用
收藏
页码:107 / +
页数:22
相关论文
共 38 条
[1]   Effects of acute prednisolone administration on exercise endurance and metabolism [J].
Arlettaz, A. ;
Collomp, K. ;
Portier, H. ;
Lecoq, A-M ;
Rieth, N. ;
Le Panse, B. ;
De Ceaurriz, J. .
BRITISH JOURNAL OF SPORTS MEDICINE, 2008, 42 (04) :250-254
[2]   Effects of acute prednisolone intake on substrate utilization during submaximal exercise [J].
Arlettaz, A. ;
Portier, H. ;
Lecoq, A. -M. ;
Labsy, Z. ;
de Ceaurriz, J. ;
Collomp, K. .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2008, 29 (01) :21-26
[3]   Effects of acute prednisolone intake during intense submaximal exercise [J].
Arlettaz, A. ;
Collomp, K. ;
Portier, H. ;
Lecoq, A. -M. ;
Pelle, A. ;
de Ceaurriz, J. .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2006, 27 (09) :673-679
[4]   Effects of short-term prednisolone intake during submaximal exercise [J].
Arlettaz, Alexandre ;
Portier, Hugues ;
Lecoq, Anne-Marie ;
Rieth, Nathalie ;
De Ceaurriz, Jacques ;
Collomp, Katia .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2007, 39 (09) :1672-1678
[5]   No variation of physical performance and perceived exertion after adrenal gland stimulation by synthetic ACTH (Synacthen®) in cyclists [J].
Baume, Norbert ;
Steel, Graeme ;
Edwards, Tony ;
Thorstensen, Eric ;
Miller, Benjamin F. .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (04) :589-600
[6]   LOW-DOSE ADRENOCORTICOTROPIN TEST REVEALS IMPAIRED ADRENAL-FUNCTION IN PATIENTS TAKING INHALED CORTICOSTEROIDS [J].
BROIDE, J ;
SOFERMAN, R ;
KIVITY, S ;
GOLANDER, A ;
DICKSTEIN, G ;
SPIRER, Z ;
WEISMAN, Y .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (04) :1243-1246
[7]   Effects of short-term glucocorticoids on cardiovascular biomarkers [J].
Brotman, DJ ;
Girod, JP ;
Garcia, MJ ;
Patel, JV ;
Gupta, M ;
Posch, A ;
Saunders, S ;
Lip, GYH ;
Worley, S ;
Reddy, S .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3202-3208
[8]  
Buttgereit F, 2005, LANCET, V365, P801
[9]  
CAPACCIO JA, 1985, MED SCI SPORT EXER, V17, P380
[10]   Short-term glucocorticoid intake combined with intense training on performance and hormonal responses [J].
Collomp, K. ;
Arlettaz, A. ;
Portier, H. ;
Lecoq, A-M ;
Le Panse, B. ;
Rieth, N. ;
De Ceaurriz, J. .
BRITISH JOURNAL OF SPORTS MEDICINE, 2008, 42 (12) :983-988