Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation

被引：335

作者：

Kartha, Reena V. ^{[1
]}

Subramanian, Subbaya ^{[2
,3
]}

机构：

[1] Univ Minnesota, Ctr Orphan Drug Res, Dept Expt & Clin Pharmacol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Surg, Div Basic & Translational Res Inst, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN 55455 USA

来源：

FRONTIERS IN GENETICS | 2014年 / 5卷

关键词：

LONG NONCODING RNAS; CIRCULAR RNAS; HEPATOCELLULAR-CARCINOMA; MESSENGER-RNAS; EMERGING ROLES; MICRORNA; CELL; TRANSCRIPTION; CANCER; PTEN;

D O I：

10.3389/fgene.2014.00008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The discovery of microRNAs (miRNAs) has led to a paradigm shift in our basic understanding of gene regulation. Competing endogenous RNAs (ceRNAs) are the recent entrants adding to the complexities of miRNA mediated gene regulation. ceRNAs are RNAs that share miRNA recognition elements (MREs) thereby regulating each other. It is apparent that miRNAs act as rheostats that fine-tune gene expression and maintain the functional balance of various gene networks. Thus MREs in coding and non-coding transcripts have evolved to become the crosstalk hubs of gene interactions, affecting the expression levels and activities of different ceRNAs. Decoding the crosstalk between MREs mediated by ceRNAs is critical to delineate the intricacies in gene regulation, and we have just begun to unravel this complexity.

引用

页数：9

共 98 条

[1] Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments [J].

Ala, Ugo ;

Karreth, Florian A. ;

Bosia, Carla ;

Pagnani, Andrea ;

Taulli, Riccardo ;

Leopold, Valentine ;

Tay, Yvonne ;

Provero, Paolo ;

Zecchina, Riccardo ;

Pandolfi, Pier Paolo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (18) :7154-7159

[2] Subtle variations in Pten dose determine cancer susceptibility [J].

Alimonti, Andrea ;

Carracedo, Arkaitz ;

Clohessy, John G. ;

Trotman, Lloyd C. ;

Nardella, Caterina ;

Egia, Ainara ;

Salmena, Leonardo ;

Sampieri, Katia ;

Haveman, William J. ;

Brogi, Edi ;

Richardson, Andrea L. ;

Zhang, Jiangwen ;

Pandolfi, Pier Paolo .

NATURE GENETICS, 2010, 42 (05) :454-U136

[3] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[4] Target mRNA abundance dilutes microRNA and siRNA activity [J].

Arvey, Aaron ;

Larsson, Erik ;

Sander, Chris ;

Leslie, Christina S. ;

Marks, Debora S. .

MOLECULAR SYSTEMS BIOLOGY, 2010, 6

[5] pho2, a phosphate overaccumulator, is caused by a nonsense mutation in a MicroRNA399 target gene [J].

Aung, Kyaw ;

Lin, Shu-I ;

Wu, Chia-Chune ;

Huang, Yu-Ting ;

Su, Chun-Lin ;

Chiou, Tzyy-Jen .

PLANT PHYSIOLOGY, 2006, 141 (03) :1000-1011

[6] Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes [J].

Balasubramanian, Suganthi ;

Zheng, Deyou ;

Liu, Yuen-Jong ;

Fang, Gang ;

Frankish, Adam ;

Carriero, Nicholas ;

Robilotto, Rebecca ;

Cayting, Philip ;

Gerstein, Mark .

GENOME BIOLOGY, 2009, 10 (01)

[7] PHO2, microRNA399, and PHR1 define a phosphate-signaling pathway in plants [J].

Bari, Rajendra ;

Pant, Bikram Datt ;

Stitt, Mark ;

Scheible, Wolf-Ruediger .

PLANT PHYSIOLOGY, 2006, 141 (03) :988-999

[8] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[9] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[10] A continuum model for tumour suppression [J].

Berger, Alice H. ;

Knudson, Alfred G. ;

Pandolfi, Pier Paolo .

NATURE, 2011, 476 (7359) :163-169

← 1 2 3 4 5 6 7 8 9 10 →