Molecular level-based bioactive glass-poly (caprolactone) hybrids monoliths with porous structure for bone tissue repair

被引:12
作者
Chen, Jing [1 ]
Que, Wenxiu [1 ]
Xing, Yonglei [1 ]
Lei, Bo [1 ]
机构
[1] Xi An Jiao Tong Univ, Elect Mat Res Lab, Int Ctr Dielectr Res, Key Lab,Minist Educ,Frontier Inst Sci & Technol, Xian 710049, Peoples R China
基金
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词
Hybrid biomaterials; Bioactive glass; Poly(epsilon-caprolactone); Sol-gel process; Bioactivity; BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; SCAFFOLDS; MATRIX;
D O I
10.1016/j.ceramint.2014.10.147
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Molecular level-based silicate bioactive glass (BG)-polymer hybrid materials have attracted much attention in bone tissue regeneration, due to their biomimetic structure and bioactivity. However, few successes have been achieved for preparing synthetic biopolymers-based bioactive glass hybrid materials, because of their non-miscible characteristic. Here, the molecular level scale bioactive glass-poly (epsilon-caprolactone) (MBG-PCL) hybrid monoliths with porous surface structure were successfully fabricated by a polydimethylsiloxane modified sol-gel technique. The as-prepared hybrid monolith presented a porous structure and crack-free morphology. The in vitro bioactivity test showed that the novel MBG-PCL hybrid structure exhibited high apatite-forming ability in simulated body fluid (SBF). The composition, porous structure, as well as high bioactivity of the hybrid monoliths make them a promising candidate as bioactive implants for bone tissue regeneration. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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页码:3330 / 3334
页数:5
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