Cancer revoked: oncogenes as therapeutic targets

被引：300

作者：

Felsher, DW

机构：

[1] Stanford Univ, Div Oncol, Dept Med, Stanford, CA 94305 USA

[2] Stanford Univ, Div Oncol, Dept Pathol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrc1070

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent findings show that even the brief inactivation of a single oncogene might be sufficient to result in the sustained loss of a neoplastic phenotype. It is therefore possible that the targeted inactivation of oncogenes could be a specific and effective treatment for cancer So why does oncogene inactivation cause tumour regression and will this be a generally successful approach for the treatment of human neoplasia?.

引用

页码：375 / 380

页数：6

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