Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line

被引：5
作者：
Yasutaka, Yuki [2 ]
Watanabe, Takuya [1 ]
Nakashima, Akio [2 ]
Matsumoto, Junichi [2 ]
Futagami, Koujiro [2 ]
Yamauchi, Atsushi [1 ]
Kataoka, Yasufumi [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmaceut Care & Hlth Sci, Jonan Ku, Fukuoka 8140180, Japan
[2] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmaceut & Hlth Care Management, Jonan Ku, Fukuoka 8140180, Japan
来源：
FEBS LETTERS | 2015年 / 589卷 / 02期
基金：
日本学术振兴会;
关键词：
Prion protein; Beta-amyloid; Brain endothelial cell; Tumor necrosis factor-alpha; Alzheimer's disease; P-GLYCOPROTEIN; TRANSPORT ACTIVITY; BARRIER; EXPRESSION; DISEASE; MODEL; BILE;
D O I：
10.1016/j.febslet.2014.12.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Disruption of beta-amyloid (Ab) transport across the blood-brain barrier is thought to cause Ab accumulation in the brain, thus leading to the development of Alzheimer's disease (AD). As AD patients show increased serum tumor necrosis factor-alpha (TNF alpha) levels, we examined the effect of TNF alpha on the function and expression of Ab transport-related proteins including cellular prion protein (PrPC) in the mouse brain microvascular endothelial cell line MBEC4. TNF alpha decreased PrPC levels and intracellular radiolabeled Ab. Similarly, anti-prion protein antibody also decreased radiolabeled Ab. These results suggest that TNF alpha lowers PrPC levels, which in turn, reduces Ab in the brain endothelium. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：263 / 268
页数：6
相关论文
共 18 条
  • [1] Tumor necrosis factor α and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
    Bauer, Bjorn
    Hartz, Anika M. S.
    Miller, David S.
    [J]. MOLECULAR PHARMACOLOGY, 2007, 71 (03) : 667 - 675
  • [2] Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1
    Bellingham, Shayne A.
    Coleman, Louise A.
    Masters, Colin L.
    Camakaris, James
    Hill, Andrew F.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (02) : 1291 - 1301
  • [3] P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
    Cirrito, JR
    Deane, R
    Fagan, AM
    Spinner, ML
    Parsadanian, M
    Finn, MB
    Jiang, H
    Prior, JL
    Sagare, A
    Bales, KR
    Paul, SM
    Zlokovic, BV
    Piwnica-Worms, D
    Holtzman, DM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) : 3285 - 3290
  • [4] The Extracellular Regulated Kinase-1 (ERK1) Controls Regulated α-Secretase-mediated Processing, Promoter Transactivation, and mRNA Levels of the Cellular Prion Protein
    Cisse, Moustapha
    Duplan, Eric
    Guillot-Sestier, Marie-Victoire
    Rumigny, Joaquim
    Bauer, Charlotte
    Pages, Gilles
    Orzechowski, Hans-Dieter
    Slack, Barbara E.
    Checler, Frederic
    Vincent, Bruno
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (33) : 29192 - 29206
  • [5] 2 MEMBERS OF THE MOUSE MDR GENE FAMILY CONFER MULTIDRUG RESISTANCE WITH OVERLAPPING BUT DISTINCT DRUG SPECIFICITIES
    DEVAULT, A
    GROS, P
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (04) : 1652 - 1663
  • [6] 1a,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells
    Durk, Matthew R.
    Chan, Gary N. Y.
    Campos, Christopher R.
    Peart, John C.
    Chow, Edwin C. Y.
    Lee, Eason
    Cannon, Ronald E.
    Bendayan, Reina
    Miller, David S.
    Pang, K. Sandy
    [J]. JOURNAL OF NEUROCHEMISTRY, 2012, 123 (06) : 944 - 953
  • [7] BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment
    Gezen-Ak, Duygu
    Dursun, Erdinc
    Hanagasi, Hasmet
    Bilgic, Basar
    Lohman, Ebba
    Araz, Omur Selin
    Atasoy, Irem L.
    Alaylioglu, Merve
    Onal, Burak
    Gurvit, Hakan
    Yilmazer, Selma
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2013, 37 (01) : 185 - 195
  • [8] Total Prion Protein Levels in the Cerebrospinal Fluid are Reduced in Patients with Various Neurological Disorders
    Meyne, Felix
    Gloeckner, Sara Friederike
    Ciesielczyk, Barbara
    Heinemann, Uta
    Krasnianski, Anna
    Meissner, Bettina
    Zerr, Inga
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2009, 17 (04) : 863 - 873
  • [9] St. John's Wort Constituents Modulate P-glycoprotein Transport Activity at the Blood-Brain Barrier
    Ott, Melanie
    Huls, Miriam
    Cornelius, Michael G.
    Fricker, Gert
    [J]. PHARMACEUTICAL RESEARCH, 2010, 27 (05) : 811 - 822
  • [10] Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier
    Pflanzner, Thorsten
    Petsch, Benjamin
    Andre-Dohmen, Bettina
    Mueller-Schiffmann, Andreas
    Tschickardt, Sabrina
    Weggen, Sascha
    Stitz, Lothar
    Korth, Carsten
    Pietrzik, Claus U.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (04) : 628 - 632
12