HUNGARIAN EXPERIENCES WITH LEVODOPA/CARBIDOPA INTESTINAL GEL IN THE TREATMENT OF ADVANCED PARKINSON'S DISEASE

被引:0
作者
Nagy, Helga [1 ,2 ]
Takats, Annannaria [1 ]
Toth, Adrian [1 ]
Bereczki, Daniel [1 ]
Klivenyi, Peter [3 ]
Dezsi, Livia [3 ]
Dibo, Gyoergy [3 ]
Vecsei, Laszlo [3 ,4 ]
Kovacs, Norbert [5 ]
Aschermann, Zsuzsa [5 ]
Komoly, Samue, I [5 ]
Varannai, Lajos [6 ]
Zemlenyi, Gyoengyi [6 ]
Valikovics, Attila [6 ]
机构
[1] Semmelweis Egyet, Neurol Klin, H-1083 Budapest, Hungary
[2] Orszagos Orvosi Rehabil Int, Budapest, Hungary
[3] Szegedi Tudomonyegyetem, Neurol Klin, Szeged, Hungary
[4] MTA SZTE, Szeged, Hungary
[5] Pecsi Tudomanyegyetem, Neurol Klin, Pecs, Hungary
[6] Borsod Abauj Zemplen Megyei Korhoz, Neurol Osztoly, Miskolc, Hungary
来源
IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE | 2014年 / 67卷 / 11-12期
关键词
advanced Parkinson's disease; motor and non - motor fluctuations; disturbing dyskinesias; effectiveness of LCIG therapy; results in Hungary; DUODENAL LEVODOPA INFUSION; CONTINUOUS DOPAMINERGIC STIMULATION; CONTINUOUS DRUG-DELIVERY; INTRAJEJUNAL LEVODOPA; NONMOTOR SYMPTOMS; MOTOR; EFFICACY; MULTICENTER; SAFETY;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the advanced Parkison's disease (PD) the late complications of levodopa therapy have to be considered: motor and/or non-motor fluctuations with or without disturbing dyskinesias. The non-motor fluctuations often influence the quality of life (QoL) in a much more negative way compared with the motor symptoms. In the treatment of advanced PD there are several device-aided methods - deep brain stimulation, apomorphine pump, levodopa/carbidopa intestinal gel (LCIG) - to improve the symptoms, the QoL, sometimes even in an individual, tailored custom form. The LCIG therapy was introduced in Hungary in 2011. Here we summarize the data of our patients: we have tested almost 60 patients and in 43 cases we have started this treatment. We analyze the duration of illness, levodopa therapy, motor and non-motor fluctuation of patients and present our experiences with the test phase and the chronic LCIG therapy via PEG/PEJ implantation. We paid attention to the surgery and device - depending side effects. Our experiences are similar to the international data. In patients selection "the right treatment, to the right patient, in the right time" is of importance.
引用
收藏
页码:385 / 389
页数:5
相关论文
共 50 条
  • [41] Impact of Disease Duration in Effectiveness of Treatment with Levodopa-Carbidopa Intestinal Gel and Factors Leading to Discontinuation
    Regidor, Ignacio
    Santos-Garcia, Diego
    Jose Catalan, Maria
    Puente, Victor
    Valldeoriola, Francesc
    Grandas, Francisco
    Mir, Pablo
    Carlos Parra, Juan
    Matias Arbelo, Jose
    [J]. JOURNAL OF PARKINSONS DISEASE, 2019, 9 (01) : 173 - 182
  • [42] Levodopa–carbidopa intrajejunal gel in advanced Parkinson disease with “on” freezing of gait
    Giovanni Cossu
    Valeria Ricchi
    Manuela Pilleri
    Francesca Mancini
    Daniela Murgia
    Gianluigi Ricchieri
    Alessandra Mereu
    Maurizio Melis
    Angelo Antonini
    [J]. Neurological Sciences, 2015, 36 : 1683 - 1686
  • [43] Levodopa-carbidopa intestinal gel in advanced Parkinson's disease open-label study: Interim results
    Fernandez, Hubert H.
    Vanagunas, Arvydas
    Odin, Per
    Espay, Alberto J.
    Hauser, Robert A.
    Standaert, David G.
    Chatamra, Krai
    Benesh, Janet
    Pritchett, Yili
    Hass, Steven L.
    Lenz, Robert A.
    [J]. PARKINSONISM & RELATED DISORDERS, 2013, 19 (03) : 339 - 345
  • [44] Long-term safety, discontinuation and mortality in an Italian cohort with advanced Parkinson's disease on levodopa/carbidopa intestinal gel infusion
    Garri, Federica
    Russo, Francesco Paolo
    Carrer, Tommaso
    Weis, Luca
    Pistonesi, Francesca
    Mainardi, Michele
    Sandre, Michele
    Savarino, Edoardo
    Farinati, Fabio
    Del Sorbo, Francesca
    Soliveri, Paola
    Calandrella, Daniela
    Biundo, Roberta
    Carecchio, Miryam
    Zecchinelli, Anna Lena
    Pezzoli, Gianni
    Antonini, Angelo
    [J]. JOURNAL OF NEUROLOGY, 2022, 269 (10) : 5606 - 5614
  • [45] Outcomes Impacting Quality of Life in Advanced Parkinson's Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel
    Kovacs, Norbert
    Bergmann, Lars
    Anca-Herschkovitsch, Marieta
    Cubo, Esther
    Davis, Thomas L.
    Iansek, Robert
    Siddiqui, Mustafa S.
    Simu, Mihaela
    Standaert, David G.
    Chaudhuri, K. Ray
    Bourgeois, Paul
    Gao, Tianming
    Kukreja, Pavnit
    Pontieri, Francesco E.
    Aldred, Jason
    [J]. JOURNAL OF PARKINSONS DISEASE, 2022, 12 (03) : 917 - 926
  • [46] Levodopa-Carbidopa Intestinal Gel Reduces Dyskinesia in Parkinson's Disease in a Randomized Trial
    Freire-Alvarez, Eric
    Kurca, Egon
    Lopez Manzanares, Lydia
    Pekkonen, Eero
    Spanaki, Cleanthe
    Vanni, Paola
    Liu, Yang
    Sanchez-Solino, Olga
    Barbato, Luigi M.
    [J]. MOVEMENT DISORDERS, 2021, 36 (11) : 2615 - 2623
  • [47] THE IMPACT OF LEVODOPA-CARBIDOPA INTESTINAL GEL ON HEALTH-RELATED QUALITY OF LIFE IN PARKINSON'S DISEASE
    Kovacs Norbert
    Aschermann Zsuzsanna
    Acs Peter
    Bosnyak Edit
    Deli Gabriella
    Janszky Jozsef
    Komoly Samuel
    [J]. IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, 2014, 67 (7-8): : 245 - 250
  • [48] The effect of levodopa-carbidopa intestinal gel infusion long-term therapy on motor complications in advanced Parkinson's disease: a multicenter Romanian experience
    Bajenaru, O.
    Ene, A.
    Popescu, B. O.
    Szasz, J. A.
    Sabau, M.
    Muresan, D. F.
    Perju-Dumbrava, L.
    Popescu, C. D.
    Constantinescu, A.
    Buraga, I.
    Simu, M.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2016, 123 (04) : 407 - 414
  • [49] Motor and non-motor outcomes in patients with advanced Parkinson's disease treated with levodopa/carbidopa intestinal gel: final results of the GREENFIELD observational study
    Lopiano, Leonardo
    Modugno, Nicola
    Marano, Pietro
    Sensi, Mariachiara
    Meco, Giuseppe
    Solla, Paolo
    Gusmaroli, Graziano
    Tamma, Filippo
    Mancini, Francesca
    Quatrale, Rocco
    Zangaglia, Roberta
    Bentivoglio, Annarita
    Eleopra, Roberto
    Gualberti, Giuliana
    Melzi, Gabriella
    Antonini, Angelo
    [J]. JOURNAL OF NEUROLOGY, 2019, 266 (09) : 2164 - 2176
  • [50] Effects of Levodopa-Carbidopa Intestinal Gel Compared with Optimized Medical Treatment on Nonmotor Symptoms in Advanced Parkinson's Disease: INSIGHTS Study
    Chung, Sun Ju
    Calopa, Matilde
    Ceravolo, Maria G.
    Tambasco, Nicola
    Antonini, Angelo
    Chaudhuri, K. Ray
    Robieson, Weining Z.
    Sanchez-Solino, Olga
    Zadikoff, Cindy
    Jin, Man
    Barbato, Luigi M.
    [J]. PARKINSONS DISEASE, 2022, 2022