A key role for the GINS complex at DNA replication forks

被引：115
|
作者：
Labib, Karim [1 ]
Gambus, Agnieszka [1 ]
机构：
[1] Univ Manchester, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England
来源：
TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 06期
关键词：
D O I：
10.1016/j.tcb.2007.04.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.
引用
收藏
页码：271 / 278
页数：8
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