Effect of weight loss on neutrophil resolvins in the metabolic syndrome

被引：27

作者：

Barden, A. ^{[1
]}

Shinde, S. ^{[1
]}

Tsai, I-J ^{[1
]}

Crof, K. D. ^{[2
]}

Beilin, L. J. ^{[1
]}

Puddey, I. B. ^{[1
]}

Mori, T. A. ^{[1
]}

机构：

[1] Univ Western Australia, Med Sch, Perth, WA, Australia

[2] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2019年 / 148卷

关键词：

Weight loss; Metabolic syndrome; Resolvins; Neutrophils; ACUTE-INFLAMMATION; PRORESOLVING MEDIATORS; LIPID MEDIATORS; OBESITY; RESOLUTION; SUPPLEMENTATION; EXPRESSION; PRESSURE; ALPHA; D1;

D O I：

10.1016/j.plefa.2019.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Non-resolving inflammation associates with obesity and insulin resistance, and may be dependent on the balance of inflammatory substances and specialised pro-resolving mediators of inflammation (SPM) that act to halt the inflammatory response. This controlled trial examined the effect of weight loss on neutrophil synthesis of SPM in volunteers with the metabolic syndrome (MetS). Methods: Volunteers with MetS (n = 42) were matched for age and gender and randomly assigned to a 12-wk weight loss program followed by 4-wk weight stabilization or a 16-wk weight maintenance program. At baseline and 16 weeks, isolated neutrophils were stimulated with calcium ionophore and the released SPM were measured by LC-MS/MS. Results: At baseline the SPM resolvin (Rv) E1, 18R-RvE3, RvD2 and Maresin-1 (MaR-1) were detected from stimulated neutrophils. The concentration of released RvE1 was at least 6-fold that of other detected SPM. Weight loss of 4.7 +/- 0.8 kg, led to a 2-fold increase in RvE1, P = 0.013, relative to the weight maintenance group. The increase in RvE1 after weight loss was related to, but independent of leukotriene B-4. Concision: Following weight loss, human neutrophils from individuals with the metabolic syndrome are capable of releasing larger amounts of RvE1 upon stimulation.

引用

页码：25 / 29

页数：5

共 39 条

[1] Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation [J].