Isolation and structure of platencin: A FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity

被引：159
作者：
Jayasuriya, Hiranthi
Herath, Kithsiri B.
Zhang, Chaowei
Zink, Deborah L.
Basilio, Angela
Genilloud, Olga
Diez, Maria Teresa
Vicente, Francisca
Gonzalez, Ignacio
Salazar, Oscar
Pelaez, Fernando
Cummings, Richard
Ha, Sookhee
Wang, Jun
Singh, Sheo B.
机构：
[1] Merck Res Labs, Rahway, NJ 07065 USA
[2] Merck Sharp & Dohme Espana, Ctr Invest Basic, E-28027 Madrid, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 25期
关键词：
antibiotics; drug discovery; inhibitors; natural products; structure elucidation;
D O I：
10.1002/anie.200701058
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Two birds with one stone: Platencin (1) is a novel and potent broad-spectrum Gram-positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF, platencin exerts its activity by a novel mode of action by dual inhibition of FabH and FabF. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：4684 / 4688
页数：5
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