Relationship between Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Gene and Fatty Acid Composition in Korean Native Cattle

被引:3
作者
Lee, Jea-young [1 ]
Ha, Jae-jung [2 ]
Park, Yong-soo [3 ]
Yi, Jun-koo [2 ]
Lee, Seunguk [4 ]
Mun, Seyoung [5 ,6 ,7 ]
Han, Kyudong [5 ,6 ,7 ]
Kim, J. -J. [8 ]
Kim, Hyun-Ji [1 ]
Oh, Dong-yep [2 ]
机构
[1] Yeungnam Univ, Dept Stat, Gyeongbuk 712749, South Korea
[2] Livestock Res Inst, Yeongju 750871, South Korea
[3] Korea Natl Coll Agr & Fisheries, Dept Equine Ind, Hwaseong 445760, South Korea
[4] Univ Tokyo, Biotechnol Res Ctr, Bunkyo Ku, Tokyo 1138657, Japan
[5] Dankook Univ, Dept Nanobiomed Sci, Cheonan 330714, South Korea
[6] Dankook Univ, PLUS NBM Global Res Ctr Regenerat Med BK21, Cheonan 330714, South Korea
[7] DKU Theragen Inst NGS Anal DTiNa, Cheonan 330714, South Korea
[8] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, South Korea
来源
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES | 2016年 / 29卷 / 02期
关键词
Korean Native Cattle; PPAR gamma; SNP; Fatty Acid Composition; Marbling Score; SUBCUTANEOUS ADIPOSE-TISSUE; PPAR-GAMMA; CARCASS CHARACTERISTICS; MEAT QUALITY; TRANSCRIPTIONAL ACTIVITY; BEEF; IDENTIFICATION; STEERS; PALATABILITY; ASSOCIATIONS;
D O I
10.5713/ajas.15.0502
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The peroxisome proliferator-activated receptor gamma (PPAR gamma) gene plays an important role in the biosynthesis process controlled by a number of fatty acid transcription factors. This study investigates the relationships between 130 single-nucleotide polymorphisms (SNPs) in the PPAR gamma gene and the fatty acid composition of muscle fat in the commercial population of Korean native cattle. We identified 38 SNPs and verified relationships between 3 SNPs (g.1159-71208 A>G, g.42555-29812 G>A, and g. 72362 G>T) and the fatty acid composition of commercial Korean native cattle (n = 513). Cattle with the AA genotype of g. 1159-71208 A>G and the GG genotype of g.42555-29812 G>A and g. 72362 G>T had higher levels of monounsaturated fatty acids and carcass traits (p<0.05). The results revealed that the 3 identified SNPs in the PPAR gamma gene affected fatty acid composition and carcass traits, suggesting that these 3 SNPs may improve the flavor and quality of beef in commercial Korean native cattle.
引用
收藏
页码:184 / 194
页数:11
相关论文
共 41 条
[1]   Quantitative trait loci with additive effects on palatability and fatty acid composition of meat in a Wagyu-Limousin F2 population [J].
Alexander, L. J. ;
MacNeil, M. D. ;
Geary, T. W. ;
Snelling, W. M. ;
Rule, D. C. ;
Scanga, J. A. .
ANIMAL GENETICS, 2007, 38 (05) :506-513
[2]  
Christine YU, 2005, J BIOL CHEM, V280, P13600
[3]   Lipid characteristics of subcutaneous adipose tissue and M-longissimus thoracis of Angus and Wagyu steers fed to US and Japanese endpoints [J].
Chung, K. Y. ;
Lunt, D. K. ;
Choi, C. B. ;
Chae, S. H. ;
Rhoades, R. D. ;
Adams, T. H. ;
Booren, B. ;
Smith, S. B. .
MEAT SCIENCE, 2006, 73 (03) :432-441
[4]   Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome [J].
Eberle, Michael A. ;
Rieder, Mark J. ;
Kruglyak, Leonid ;
Nickerson, Deborah A. .
PLOS GENETICS, 2006, 2 (09) :1319-1327
[5]  
Falconer D. S., 1996, Introduction to quantitative genetics.
[6]   Three novel SNPs in the coding region of PPARγ gene and their associations with meat quality traits in cattle [J].
Fan, Yue Yuan ;
Zan, Lin Sen ;
Fu, Chang Zhen ;
Tian, Wan Qiang ;
Wang, Hong Bao ;
Liu, Yan Yan ;
Xin, Ya Ping .
MOLECULAR BIOLOGY REPORTS, 2011, 38 (01) :131-137
[7]  
FOLCH J, 1957, J BIOL CHEM, V226, P497
[8]   Corepressors selectively control the transcriptional activity of PPARγ in adipocytes [J].
Guan, HP ;
Ishizuka, T ;
Chui, PC ;
Lehrke, M ;
Lazar, MA .
GENES & DEVELOPMENT, 2005, 19 (04) :453-461
[9]   Genotype of bovine sterol regulatory element binding protein-1 (SREBP-1) is associated with fatty acid composition in Japanese Black cattle [J].
Hoashi, Shogo ;
Ashida, Nobuhisa ;
Ohsaki, Hideki ;
Utsugi, Takeshi ;
Sasazaki, Shinji ;
Taniguchi, Masaaki ;
Oyama, Kenji ;
Mukai, Fumio ;
Mannen, Hideyuki .
MAMMALIAN GENOME, 2007, 18 (12) :880-886
[10]  
Hua LS, 2011, AFR J BIOTECHNOL, V10, P2785