Preoperative duloxetine on postoperative pain after laparoscopic gynecological surgeries: A systematic review and meta-analysis of randomized controlled trials

被引：4

作者：

Baradwan, Saeed ^{[1
]}

Alshahrani, Majed Saeed ^{[2
]}

Alkhamis, Waleed H. ^{[3
]}

Allam, Hassan Saleh ^{[4
,5
]}

AlSghan, Rayan ^{[6
]}

Ghazi, Ahmed ^{[7
]}

Ragab, Bassem ^{[8
]}

Elmazzaly, Saged Mohamed Metyli ^{[8
]}

Aboshama, Rehab Abdelhamid ^{[9
]}

Ismail, Reda A. ^{[10
]}

Dahshan, Shaimaa A. ^{[10
]}

Al-Touny, Aiman A. ^{[10
]}

Daghash, Noha H. ^{[11
]}

Abdelhakim, Ahmed Mohamed ^{[12
]}

Abbas, Ahmed M. ^{[13
]}

Fouda, Albayoumi A. ^{[14
]}

Abdelfattah, Laila Ezzat ^{[9
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Jeddah, Saudi Arabia

[2] Najran Univ, Fac Med, Dept Obstet & Gynecol, Najran, Saudi Arabia

[3] King Saud Univ, King Saud Univ Med City, Coll Med, Dept Obstet & Gynecol, Riyadh, Saudi Arabia

[4] Prince Sultan Mil Med City, Dept Obstet & Gynecol, Riyadh, Saudi Arabia

[5] King Abdulaziz Univ, Rabigh Med Coll, Dept Obstet & Gynecol, Jeddah, Saudi Arabia

[6] Matern & Children Hosp, Dept Obstet & Gynecol, Alkharj, Saudi Arabia

[7] Jeddah Univ, Coll Med, Dept Obstet & Gynecol, Jeddah, Saudi Arabia

[8] Al Azhar Univ, Fac Med, Dept Obstet & Gynecol, Cairo, Egypt

[9] Fayoum Univ, Fac Med, Dept Obstet & Gynecol, Al Fayyum, Egypt

[10] Suez Canal Univ, Fac Med, Dept Anesthesia & Intens Care, Ismailia, Egypt

[11] Assiut Univ, Fac Med, Dept Anesthesia & Intens Care, Assiut, Egypt

[12] Cairo Univ, Fac Med, Kasralainy, Cairo, Egypt

[13] Assiut Univ, Fac Med, Dept Obstet & Gynecol, Assiut, Egypt

[14] Al Azhar Univ, Fac Med, Dept Med Physiol, Cairo, Egypt

来源：

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION | 2022年 / 51卷 / 03期

关键词：

Duloxetine; Postoperative pain; Gynecologic laparoscopy; Postoperative analgesia; SEX;

D O I：

10.1016/j.jogoh.2021.102305

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the efficacy and safety of preoperative duloxetine on postoperative pain management after gynecologic laparoscopic surgeries.Methods: A systematic search was done in Cochrane Library, PubMed, ISI web of science, and Scopus from inception to September 2021. We selected randomized clinical trials (RCTs) that compared preoperative duloxetine (intervention group) versus placebo (control group) among women undergoing gynecologic lapa-roscopic surgeries. Our primary outcomes were pain scores evaluated by the Visual Analog Scale (VAS) at 2, 6, 12, and 24 h postoperatively. Our secondary outcomes were the time required for the first analgesic request in minutes, postoperative analgesic consumption in milligrams, length of hospital stay in days, and side effects.Results: Four RCTs with a total number of 244 patients were included in our systematic review and meta -analysis. We found duloxetine was linked to a significant reduction in VAS pain scores at different time inter -vals. The first analgesic request was significantly earlier in the placebo group than in the duloxetine group (p = 0.03). In addition, duloxetine significantly reduced the postoperative analgesic consumption compared to placebo (MD=-41.97, 95% CI [-53.23,-30.72], p<0.001). However, both groups did not differ in the length of hospital stay and side effects.Conclusions: Duloxetine administration prior to gynecological laparoscopic surgeries is safe and effective in improving postoperative pain and analgesia.(c) 2022 Elsevier Masson SAS. All rights reserved.

引用

页数：7

共 29 条

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