Simulations of lipid transfer between a supported lipid bilayer and adsorbing vesicles

被引:4
作者
Dimitrievski, Kristian [1 ]
Kasemo, Bengt [1 ]
机构
[1] Chalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
基金
瑞典研究理事会;
关键词
Lipid transfer; Lipid exchange; Supported lipid bilayer; Vesicle-lipid bilayer interactions; Vesicle adsorption; Lipid mixture; Monte Carlo simulation; OPPOSITELY CHARGED VESICLES; COMPUTER-SIMULATION; MEMBRANES; PHOSPHATIDYLCHOLINE; EXCHANGE; ADSORPTION; DYNAMICS; DENSITY; FUSION;
D O I
10.1016/j.colsurfb.2009.09.019
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Recent experiments demonstrate transfer of lipid molecules between a charged, supported lipid membrane (SLB) and vesicles of opposite charge when the latter adsorb on the SLB. A simple phenomenological bead model has been developed to simulate this process. Beads were defined to be of three types, 'n', 'p', and '0', representing POPS (negatively charged), POEPC (positively charged), and POPC (neutral but zwitterionic) lipids, respectively. Phenomenological bead-bead interaction potentials and lipid transfer rate constants were used to account for the overall interaction and transfer kinetics. Using different bead mixtures in both the adsorbing vesicle and in the SLB (representing differently composed/charged vesicles and SLBs as in the reported experiments), we clarify under which circumstances a vesicle adsorbs to the SLB, and whether it, after lipid transfer and changed composition of the SLB and vesicle, desorbs back to the bulk again or not. With this model we can reproduce and provide a conceptual picture for the experimental findings. (C) 2009 Elsevier B.V. All Fights reserved.
引用
收藏
页码:454 / 465
页数:12
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