Integrated patient and tumor genetic testing for individualized cancer therapy

被引：16

作者：

Hertz, D. L. ^{[1
]}

McLeod, H. L. ^{[2
]}

机构：

[1] Univ Michigan, Coll Pharm, Dept Clin Pharm, 428 Church St, Ann Arbor, MI 48109 USA

[2] Univ S Florida, H Lee Moffitt Canc Ctr, DeBartolo Family Personalized Med Inst, Div Populat Sci, Tampa, FL 33682 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 02期

关键词：

IMPLEMENTATION;

D O I：

10.1002/cpt.294

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor.

引用

页码：143 / 146

页数：4

共 10 条

[1] DNA Sequencing of Cancer: What Have We Learned? [J].

Chmielecki, Juliann ;

Meyerson, Matthew .

ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :63-79

[2] Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers [J].

Dunnenberger, Henry M. ;

Crews, Kristine R. ;

Hoffman, James M. ;

Caudle, Kelly E. ;

Broeckel, Ulrich ;

Howard, Scott C. ;

Hunkler, Robert J. ;

Klein, Teri E. ;

Evans, William E. ;

Relling, Mary V. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55, 2015, 55 :89-+

[3] Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era [J].

Gillis, N. K. ;

Patel, J. N. ;

Innocenti, F. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (03) :269-280

[4] ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing [J].

Green, Robert C. ;

Berg, Jonathan S. ;

Grody, Wayne W. ;

Kalia, Sarah S. ;

Korf, Bruce R. ;

Martin, Christa L. ;

McGuire, Amy L. ;

Nussbaum, Robert L. ;

O'Daniel, Julianne M. ;

Ormond, Kelly E. ;

Rehm, Heidi L. ;

Watson, Michael S. ;

Williams, Marc S. ;

Biesecker, Leslie G. .

GENETICS IN MEDICINE, 2013, 15 (07) :565-574

[5] Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400 [J].

Herbst, Roy S. ;

Gandara, David R. ;

Hirsch, Fred R. ;

Redman, Mary W. ;

LeBlanc, Michael ;

Mack, Philip C. ;

Schwartz, Lawrence H. ;

Vokes, Everett ;

Ramalingam, Suresh S. ;

Bradley, Jeffrey D. ;

Sparks, Dana ;

Zhou, Yang ;

Miwa, Crystal ;

Miller, Vincent A. ;

Yelensky, Roman ;

Li, Yali ;

Allen, Jeff D. ;

Sigal, Ellen V. ;

Wholley, David ;

Sigman, Caroline C. ;

Blumenthal, Gideon M. ;

Malik, Shakun ;

Kelloff, Gary J. ;

Abrams, Jeffrey S. ;

Blanke, Charles D. ;

Papadimitrakopoulou, Vassiliki A. .

CLINICAL CANCER RESEARCH, 2015, 21 (07) :1514-1524

[6] Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations [J].

Hyman, David M. ;

Puzanov, Igor ;

Subbiah, Vivek ;

Faris, Jason E. ;

Chau, Ian ;

Blay, Jean-Yves ;

Wolf, Juergen ;

Raje, Noopur S. ;

Diamond, Eli L. ;

Hollebecque, Antoine ;

Gervais, Radj ;

Elena Elez-Fernandez, Maria ;

Italiano, Antoine ;

Hofheinz, Ralf-Dieter ;

Hidalgo, Manuel ;

Chan, Emily ;

Schuler, Martin ;

Lasserre, Susan Frances ;

Makrutzki, Martina ;

Sirzen, Florin ;

Veronese, Maria Luisa ;

Tabernero, Josep ;

Baselga, Jose .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (08) :726-736

[7] Mutational landscape and significance across 12 major cancer types [J].

Kandoth, Cyriac ;

McLellan, Michael D. ;

Vandin, Fabio ;

Ye, Kai ;

Niu, Beifang ;

Lu, Charles ;

Xie, Mingchao ;

Zhang, Qunyuan ;

McMichael, Joshua F. ;

Wyczalkowski, Matthew A. ;

Leiserson, Mark D. M. ;

Miller, Christopher A. ;

Welch, John S. ;

Walter, Matthew J. ;

Wendl, Michael C. ;

Ley, Timothy J. ;

Wilson, Richard K. ;

Raphael, Benjamin J. ;

Ding, Li .

NATURE, 2013, 502 (7471) :333-+

[8] CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network [J].

Relling, M. V. ;

Klein, T. E. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (03) :464-467

[9] Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study [J].

Roychowdhury, Sameek ;

Iyer, Matthew K. ;

Robinson, Dan R. ;

Lonigro, Robert J. ;

Wu, Yi-Mi ;

Cao, Xuhong ;

Kalyana-Sundaram, Shanker ;

Sam, Lee ;

Balbin, O. Alejandro ;

Quist, Michael J. ;

Barrette, Terrence ;

Everett, Jessica ;

Siddiqui, Javed ;

Kunju, Lakshmi P. ;

Navone, Nora ;

Araujo, John C. ;

Troncoso, Patricia ;

Logothetis, Christopher J. ;

Innis, Jeffrey W. ;

Smith, David C. ;

Lao, Christopher D. ;

Kim, Scott Y. ;

Roberts, J. Scott ;

Gruber, Stephen B. ;

Pienta, Kenneth J. ;

Talpaz, Moshe ;

Chinnaiyan, Arul M. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (111)

[10]

Wetterstrand, DNA SEQUENCING COSTS

← 1 →