Disease burden of inflammatory bowel disease in China from 1990 to 2017: Findings from the global burden of diseases 2017

Background: A comprehensive evaluation of the burden of inflammation bowel disease (IBD) is important for identifying potential strategies to control the disease. We present results from the Global Burden of Diseases (GBD) 2017 of IBD at the national level, the trends in disease burden and its epidemiological features in China. Methods: Using the methods and results from GBD 2017, we describe the IBD burden based on the prevalence, incidence, mortality, years of lost (YLLs), the years of life lived with disability (YLDs) and disabilityadjusted life years (DALYs) in China estimated using DisMod-MR 2.1. We additionally evaluated the rate of DALYs at national locations in 2017. Findings: From 1990 to 2017, the cases, deaths, YLLs, YLDs and DALYs for IBD in China were from 1,047,991 to 2,665,081, from 5701 to 5198, from 188,814 to 107,373, from 157,581 to 394,887, from 346,396 to 502,260, respectively. Increasing trends were observed in prevalence (APC: 2.9%), incidence (APC: 1.1%), DALYs (APC: 0.8%) and YLDs (APC:2.9%). There were decreasing trends in mortality (APC: -1.0%) and YLLs (APC: -2.7%). As to the age-standardized rates of DALYs, it observed a decreasing trend (APC: -0.78%). Similar trends were observed in men and women. The age-standardized APCs in incidence, mortality and rate of YLLs among women were higher than those among men. The age-standardized rate of DALYs was 27.51 per 100,000 in 2017. Interpretation: Between 1990 and 2017, China experienced a decrease in the age-standardized DALYs, mortality rates and YLLs due to IBD, despite an increase in the age-standardized rate of prevalence, incidence and YLDs. China is still one of the low endemic areas. (C) 2020 The Author(s). Published by Elsevier Ltd.