Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNFα inhibitory activity of two series of rolipram analogues:: Implications for a new active site model of PDE4

被引：62

作者：

Kleinman, EF ^{[1
]}

Campbell, E ^{[1
]}

Giordano, LA ^{[1
]}

Cohan, VL ^{[1
]}

Jenkinson, TH ^{[1
]}

Cheng, JB ^{[1
]}

Shirley, JT ^{[1
]}

Pettipher, ER ^{[1
]}

Salter, ED ^{[1
]}

Hibbs, TA ^{[1
]}

DiCapua, FM ^{[1
]}

Bordner, J ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 03期

关键词：

D O I：

10.1021/jm970685m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：266 / 270

页数：5

共 25 条

[21] Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (01) : 24 - 29
[22] The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNF alpha) production in mice: Effect of adrenalectomy
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[23] 4-Amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships
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JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (06) : 2472 - 2489
[24] AWD 12-281, a new potent PDE4 inhibitor:: In vitro activity and effect on bronchial hyperreactivity (BHR) in BP-2 mice
Küsters, S
Marx, D
Röllig, H
Rudert, J
Szelenyi, J
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) : A114 - A114
[25] Novel selective PDE4 inhibitors.: 3.: In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones
Van der Mey, M
Boss, H
Hatzelmann, A
Van der Laan, IJ
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