Enantioselective Synthesis of Tetrahydroquinolines by Borrowing Hydrogen Methodology: Cooperative Catalysis by an Achiral Iridacycle and a Chiral Phosphoric Acid

被引：110

作者：

Lim, Ching Si ^{[1
]}

Thanh Truong Quach ^{[1
]}

Zhao, Yu ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 25期

基金：

新加坡国家研究基金会;

关键词：

amination; borrowing hydrogen; cooperative catalysis; enantioselectivity; tetrahydroquinolines; ASYMMETRIC TRANSFER HYDROGENATION; HYDROAMINATION/ASYMMETRIC TRANSFER HYDROGENATION; HETEROAROMATIC-COMPOUNDS; REDUCTIVE AMINATION; ENANTIOPURE AMINES; QUINOLINIUM SALTS; C-H; ALCOHOLS; IRIDIUM; METAL;

D O I：

10.1002/anie.201703704

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the highly enantioselective synthesis of 2-substituted tetrahydroquinolines through borrowing hydrogen, a process recognized for its environmentally benign and atom-economical nature. The use of an achiral iridacycle complex in combination with a chiral phosphoric acid as catalysts was the key to the development of this highly efficient and enantioselective transformation.

引用

页码：7176 / 7180

页数：5

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