Molecular characterization of a Newcastle disease virus isolate from a diseased chicken in the Philippines in 2017

被引：3

作者：

Giang Thi Huong Tran ^{[1
,2
,3
]}

Mananggit, Milagros Reyes ^{[4
]}

Abao, Lary Nel Bilbao ^{[5
]}

Hieu Van Dong ^{[1
,2
,3
]}

Takeda, Yohei ^{[6
]}

Ogawa, Haruko ^{[1
,2
]}

Imai, Kunitoshi ^{[1
]}

机构：

[1] Obihiro Univ Agr & Vet Med, Dept Vet Med, 2-11 Inada, Obihiro, Hokkaido 0808555, Japan

[2] Gifu Univ, United Grad Sch Vet Sci, Gifu, Gifu 5011193, Japan

[3] Vietnam Natl Univ Agr, Fac Vet Med, Hanoi, Vietnam

[4] Dept Agr, Reg Anim Dis Diagnost Lab, Field Off 3, San Fernando 2000, Pampanga, Philippines

[5] Dept Agr, Agribusiness & Mkt Assistance Serv, Ellipt Rd, Quezon City 1101, Philippines

[6] Obihiro Univ Agr & Vet Med, Res Ctr Global Agromed, 2-11 Inada, Obihiro, Hokkaido 0808555, Japan

来源：

JAPANESE JOURNAL OF VETERINARY RESEARCH | 2021年 / 69卷 / 01期

关键词：

Genotype VII; Newcastle disease virus; The Philippines; PROTEIN CLEAVAGE SITE; LIVE BIRD MARKETS; VACCINATED CHICKENS; GENETIC DIVERSITY; HN PROTEIN; FARMS; IDENTIFICATION; CHALLENGE; SEQUENCES; GENOTYPES;

D O I：

10.14943/jjvr.69.1.73

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Newcastle disease (ND) is one of the most serious diseases affecting numerous avian species worldwide. However, data on the genetic characterization of ND virus (NDV) in the Philippines are limited. Herein, the complete sequences of the fusion (F) and hemagglutinin-neuraminidase (HN) genes of a NDV strain isolated in Central Luzon in 2017 were genetically analyzed. The results revealed that the field isolate belonged to subgenotype VII.2 and the genome encoded the amino acid sequence of the F0 protein proteolytic cleavage site motif (R-112-R-Q-K-R-F-117), indicating that it was a virulent strain. The current NDV strain was genetically related to Indonesian and Israeli NDV strains. Some amino acid substitutions were found in the transmembrane domain and neutralizing epitopes of the HN protein.

引用

页码：73 / 81

页数：9

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