The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: A new approach to 2,3-disubstituted indoles

被引：141

作者：

Shen, M ^{[1
]}

Li, GS ^{[1
]}

Lu, BZ ^{[1
]}

Hossain, A ^{[1
]}

Roschangar, F ^{[1
]}

Farina, V ^{[1
]}

Senanayake, CH ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Richmond, VA 23219 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol048114t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.

引用

页码：4129 / 4132

页数：4

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