Trans Fatty Acid-Induced NF-κB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

被引：11

作者：

Hommelberg, Pascal P. H. ^{[1
,2
,3
]}

Langen, Ramon C. J.

Schols, Annemie M. W. J. ^{[1
]}

van Essen, Anon L. M. ^{[1
]}

Snepvangers, Frank J. M. ^{[1
]}

Mensink, Ronald P. ^{[2
,3
]}

Plat, Jogchum ^{[2
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Resp Med, Nutrim Sch Nutr Toxicol & Metab, Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Nutrim Sch Nutr Toxicol & Metab, Dept Human Biol, NL-6200 MD Maastricht, Netherlands

[3] Top Inst Food & Nutr, Wageningen, Netherlands

来源：

LIPIDS | 2010年 / 45卷 / 03期

关键词：

Insulin resistance; NF-kappa B; Skeletal muscle; Saturated fatty acids; Unsaturated fatty acids; C2C12; cells; L6; CONJUGATED LINOLEIC-ACID; PROTEIN-KINASE-C; MYOGENIC DIFFERENTIATION; LIPID-PEROXIDATION; GLUCOSE-TOLERANCE; PREVENTS TRANS-10; OBESE MEN; PALMITATE; RAT; CERAMIDE;

D O I：

10.1007/s11745-010-3388-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-chain saturated fatty acids such as palmitic acid induce insulin resistance and NF-kappa B activation in skeletal muscle cells. Here we investigated the effects of long-chain fatty acid (FA) saturation and configuration on NF-kappa B activity and insulin sensitivity in cultured skeletal muscle cells. Of all tested unsaturated FAs, only elaidic acid (3-fold), cis9, trans11-CLA (3-fold) and trans10, cis12-CLA (13-fold) increased NF-kappa B transactivation in myotubes. This was not accompanied by decreased insulin sensitivity (measured as insulin-induced glucose uptake and GLUT4 translocation). We therefore conclude that FA-induced NF-jB activation is not sufficient for the induction of insulin resistance in skeletal muscle cells.

引用

页码：285 / 290

页数：6

共 43 条

[1] Major advances associated with the biosynthesis of milk [J].