Trans Fatty Acid-Induced NF-κB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

被引：11
作者：
Hommelberg, Pascal P. H. [1 ,2 ,3 ]
Langen, Ramon C. J.
Schols, Annemie M. W. J. [1 ]
van Essen, Anon L. M. [1 ]
Snepvangers, Frank J. M. [1 ]
Mensink, Ronald P. [2 ,3 ]
Plat, Jogchum [2 ]
机构：
[1] Maastricht Univ, Med Ctr, Dept Resp Med, Nutrim Sch Nutr Toxicol & Metab, Maastricht, Netherlands
[2] Maastricht Univ, Med Ctr, Nutrim Sch Nutr Toxicol & Metab, Dept Human Biol, NL-6200 MD Maastricht, Netherlands
[3] Top Inst Food & Nutr, Wageningen, Netherlands
来源：
LIPIDS | 2010年 / 45卷 / 03期
关键词：
Insulin resistance; NF-kappa B; Skeletal muscle; Saturated fatty acids; Unsaturated fatty acids; C2C12; cells; L6; CONJUGATED LINOLEIC-ACID; PROTEIN-KINASE-C; MYOGENIC DIFFERENTIATION; LIPID-PEROXIDATION; GLUCOSE-TOLERANCE; PREVENTS TRANS-10; OBESE MEN; PALMITATE; RAT; CERAMIDE;
D O I：
10.1007/s11745-010-3388-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long-chain saturated fatty acids such as palmitic acid induce insulin resistance and NF-kappa B activation in skeletal muscle cells. Here we investigated the effects of long-chain fatty acid (FA) saturation and configuration on NF-kappa B activity and insulin sensitivity in cultured skeletal muscle cells. Of all tested unsaturated FAs, only elaidic acid (3-fold), cis9, trans11-CLA (3-fold) and trans10, cis12-CLA (13-fold) increased NF-kappa B transactivation in myotubes. This was not accompanied by decreased insulin sensitivity (measured as insulin-induced glucose uptake and GLUT4 translocation). We therefore conclude that FA-induced NF-jB activation is not sufficient for the induction of insulin resistance in skeletal muscle cells.
引用
收藏
页码：285 / 290
页数：6
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