Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

被引：6

作者：

Chen, Qiao-Hong ^{[2
]}

Ganesh, Thota ^{[2
]}

Jiang, Yi ^{[1
]}

Banerjee, Abhijit ^{[3
]}

Sharma, Shubhada ^{[3
]}

Bane, Susan ^{[1
]}

Snyder, James P. ^{[1
]}

Kingston, David G. I. ^{[2
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[2] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[3] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 12期

关键词：

MICROTUBULE-STABILIZING AGENTS; COMMON PHARMACOPHORE; NATURAL-PRODUCTS; TUBULIN; CONFORMATION; ANALOGS; TAXOL; ALCOHOLS; BINDING; CELLS;

D O I：

10.1039/b926174e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.

引用

页码：2019 / 2021

页数：3

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