PLCζ, a sperm-specific PLC and its potential role in fertilization

被引：58
作者：
Saunders, Christopher M.
Swann, Karl
Lai, F. Anthony [1 ]
机构：
[1] Cardiff Univ, Sch Med, Heart Res Inst, Cell Signalling Lab, Cardiff CF14 4XN, Wales
[2] Cardiff Univ, Sch Med, Dept Obstet & Gynaecol, Cardiff CF14 4XN, Wales
来源：
CELL BIOLOGY OF INOSITOL LIPIDS AND PHOSPHATES | 2007年 / 74卷
基金：
英国惠康基金;
关键词：
D O I：
10.1042/BSS2007c03
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A dramatic rise in intracellular calcium plays a vital role at the moment of fertilization, eliciting the resumption of melosis and the initiation of embryo development. In mammals, the rise takes the form of oscillations in calcium concentration within the egg, driven by an elevation in inositol trisphosphate. The causative agent of these oscillations is proposed to be a recently described phosphoinositide-specific phospholipase C, PLC, a soluble sperm protein that is delivered into the egg following membrane fusion. In the present review, we examine some of the distinctive structural and functional characteristics of this crucial enzyme that sets it apart from the other known forms of mammalian PLC.
引用
收藏
页码：23 / 36
页数：14
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