Roles of Circular RNAs in Neurologic Disease

被引：97
作者：
Shao, Yiye [1 ,2 ]
Chen, Yinghui [1 ,2 ]
机构：
[1] Fudan Univ, Dept Neurol, Jinshan Hosp, Shanghai 200433, Peoples R China
[2] Fudan Univ, Dept Neurol, Shanghai Med Coll, Shanghai 200433, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2016年 / 9卷
基金：
中国国家自然科学基金;
关键词：
circular RNA; non-coding RNA; neurological disease; microRNA; pathogenesis; CELLULAR PRION PROTEIN; CEREBELLAR DEGENERATION; MICRORNA-7; EXPRESSION; CANCER; PLASTICITY; MOLECULES; BIOMARKER; ABUNDANT; GROWTH;
D O I：
10.3389/fnmol.2016.00025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Circular RNAs (circRNAs) are a novel type of endogenous noncoding RNA receiving increasing attention. They have been shown to act as a natural microRNA sponges that repress the activity of corresponding miRNAs by binding with them, thus regulating target genes. Numerous studies have shown that miRNAs are involved in the pathogenesis of neurological diseases. Therefore, circRNAs may act as important regulatory factors in the occurrence and development processes of neurological disease.
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页数：5
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