Epstein-Barr virus: exploiting the immune system by interfering with defective ribosomal products

被引：8
作者：
Apcher, S
Fahraeus, R
Manoury, B
机构：
[1] Inst Curie, U520, F-75005 Paris, France
[2] Hop St Louis, Inst Pharmacol, EP10334, F-75010 Paris, France
来源：
MICROBES AND INFECTION | 2004年 / 6卷 / 13期
关键词：
MHC class I antigen-presentation; Epstein-Barr virus; defective ribosomal products; translation; proteasome;
D O I：
10.1016/j.micinf.2004.08.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interaction of cytotoxic T lymphocytes with major histocompatibility complex (MHC)-peptide complexes is a critical step toward the initiation and propagation of specific immune responses against viral infection. Here we review new evidence, taking Epstein-Barr virus as an example, showing that defective ribosomal products provide an important supply of endogenous peptides for entry into the MHC class I antigen-presentation pathway. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码：1212 / 1218
页数：7
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