Stress-induced obesity and the emotional nervous system

被引:530
作者
Dallman, Mary F. [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
关键词
FOOD-INTAKE; ENERGY-BALANCE; WEIGHT CHANGE; GLUCOCORTICOID-RECEPTOR; EATING-DISORDERS; DAILY HASSLES; LARD INTAKE; HPA AXIS; BRAIN; INSULIN;
D O I
10.1016/j.tem.2009.10.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Stress and emotional brain networks foster eating behaviors that can lead to obesity. The neural networks underlying the complex interactions among stressors, body, brain and food intake are now better understood. Stressors, by activating a neural stress-response network, bias cognition toward increased emotional activity and degraded executive function. This causes formed habits to be used rather than a cognitive appraisal of responses. Stress also induces secretion of glucocorticoids, which increases motivation for food, and insulin, which promotes food intake and obesity. Pleasurable feeding then reduces activity in the stress-response network, reinforcing the feeding habit. These effects of stressors emphasize the importance of teaching mental reappraisal techniques to restore responses from habitual to thoughtful, thus battling stress-induced obesity.
引用
收藏
页码:159 / 165
页数:7
相关论文
共 105 条
  • [11] Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
    Colman, Ricki J.
    Anderson, Rozalyn M.
    Johnson, Sterling C.
    Kastman, Erik K.
    Kosmatka, Kristopher J.
    Beasley, T. Mark
    Allison, David B.
    Cruzen, Christina
    Simmons, Heather A.
    Kemnitz, Joseph W.
    Weindruch, Richard
    [J]. SCIENCE, 2009, 325 (5937) : 201 - 204
  • [12] Predictors of amygdala activation during the processing of emotional stimuli: A meta-analysis of 385 PET and fMRI studies
    Costafreda, Sergi G.
    Brammer, Michael J.
    David, Anthony S.
    Fu, Cynthia H. Y.
    [J]. BRAIN RESEARCH REVIEWS, 2008, 58 (01) : 57 - 70
  • [13] How do you feel - now? The anterior insula and human awareness
    Craig, A. D.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2009, 10 (01) : 59 - 70
  • [14] How do you feel? Interoception: the sense of the physiological condition of the body
    Craig, AD
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) : 655 - 666
  • [15] Neural correlates of dispositional mindfulness during affect labeling
    Creswell, J. David
    Way, Baldwin M.
    Eisenberger, Naomi I.
    Lieberman, Matthew D.
    [J]. PSYCHOSOMATIC MEDICINE, 2007, 69 (06): : 560 - 565
  • [16] Neural mechanisms of autonomic, affective, and cognitive integration
    Critchley, HD
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2005, 493 (01) : 154 - 166
  • [17] Glucocorticoids, the etiology of obesity and the metabolic syndrome
    Dallman, Mary F.
    Akana, Susan F.
    Pecoraro, Norman C.
    Warne, James P.
    la Fleur, Susanne E.
    Foster, Michelle T.
    [J]. CURRENT ALZHEIMER RESEARCH, 2007, 4 (02) : 199 - 204
  • [18] Glucocorticoids, chronic stress, and obesity
    Dallman, Mary F.
    Pecoraro, Norman C.
    La Fleur, Susanne E.
    Warne, James P.
    Ginsberg, Abigail B.
    Akana, Susan F.
    Laugero, Kevin C.
    Houshyar, Hani
    Strack, Alison M.
    Bhatnagar, Seema
    Bell, Mary E.
    [J]. HYPOTHALAMIC INTEGRATION OF ENERGY METABOLISM, 2006, 153 : 75 - 105
  • [19] Fast glucocorticoid actions on brain: Back to the future
    Dallman, MF
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2005, 26 (3-4) : 103 - 108
  • [20] Chronic stress and comfort foods: Self-medication and abdominal obesity
    Dallman, MF
    Pecoraro, NC
    la Fleur, SE
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2005, 19 (04) : 275 - 280