Asymmetric fluorinative dearomatization of tryptamine derivatives

被引：48

作者：

Liang, Xiao-Wei ^{[1
]}

Liu, Chuan ^{[1
]}

Zhang, Wei ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 40期

关键词：

PHASE-TRANSFER CATALYSIS; ALLYLIC DEAROMATIZATION; ENANTIOSELECTIVE CONSTRUCTION; BRONSTED ACIDS; INDOLES; ACTIVATION; PHENOLS; FLUOROCYCLIZATIONS; CHLOROCYCLIZATION; ALKYLATION;

D O I：

10.1039/c7cc02419c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An asymmetric fluorinative dearomatization reaction of tryptamine derivatives was developed by using a chiral anion phase transfer catalyst (PTC) system, and the preliminary results of the reaction mechanistic study were achieved. This method is characterized by a simple operation, facile introduction of a fluorine atom in a highly enantioselective manner and construction of two contiguous quaternary stereogenic centers.

引用

页码：5531 / 5534

页数：4

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