Asymmetric fluorinative dearomatization of tryptamine derivatives

被引：46
作者：
Liang, Xiao-Wei [1 ]
Liu, Chuan [1 ]
Zhang, Wei [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 40期
关键词：
PHASE-TRANSFER CATALYSIS; ALLYLIC DEAROMATIZATION; ENANTIOSELECTIVE CONSTRUCTION; BRONSTED ACIDS; INDOLES; ACTIVATION; PHENOLS; FLUOROCYCLIZATIONS; CHLOROCYCLIZATION; ALKYLATION;
D O I：
10.1039/c7cc02419c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An asymmetric fluorinative dearomatization reaction of tryptamine derivatives was developed by using a chiral anion phase transfer catalyst (PTC) system, and the preliminary results of the reaction mechanistic study were achieved. This method is characterized by a simple operation, facile introduction of a fluorine atom in a highly enantioselective manner and construction of two contiguous quaternary stereogenic centers.
引用
收藏
页码：5531 / 5534
页数：4
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