Virus therapy for bladder cancer

被引：18
作者：
Burke, James
机构：
[1] Billings Clinic, Department of Hematology and Oncology
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 2-3期
关键词：
Bladder cancer; Virus therapy; Immunotherapy; Adenovirus; GM-CSF; Gene therapy; CG0070; Vaccinia; CALMETTE-GUERIN; GENE-THERAPY; PHASE-I; VECTOR; CARCINOMA;
D O I：
10.1016/j.cytogfr.2010.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Approximately 50,000 cases of superficial bladder cancer are diagnosed annually in the United States. Immunotherapy utilizing intravesical BCG is the most effective standard therapy for superficial transitional cell carcinoma of the bladder. Based on ease of administration, limited systemic dissemination, and the demonstrated activity of immunotherapy, superficial bladder cancer is an excellent target for virus based gene and immunotherapy. Thus far, clinical trials of virus therapy for bladder cancer have yielded mixed results. In this paper the results of several virus based clinical trials for bladder cancer are reviewed. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：99 / 102
页数：4
相关论文
共 8 条
[1]  
*AM CANC SOC, 2007, FACTS FIG 2007
[2]   Phase I study of intravesical vaccinia virus as a vector for gene therapy of bladder cancer [J].
Gomella, LG ;
Mastrangelo, MJ ;
McCue, PA ;
Maguire, HC ;
Mulholland, SG ;
Lattime, EC .
JOURNAL OF UROLOGY, 2001, 166 (04) :1291-1295
[3]   Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation [J].
Kuball, J ;
Wen, SF ;
Leissner, J ;
Atkins, D ;
Meinhardt, P ;
Quijano, E ;
Engler, H ;
Hutchins, B ;
Maneval, DC ;
Grace, MJ ;
Fritz, MA ;
Störkel, S ;
Thüroff, JW ;
Huber, C ;
Schuler, M .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (04) :957-965
[4]   A RANDOMIZED TRIAL OF INTRAVESICAL DOXORUBICIN AND IMMUNOTHERAPY WITH BACILLE CALMETTE-GUERIN FOR TRANSITIONAL-CELL CARCINOMA OF THE BLADDER [J].
LAMM, DL ;
BLUMENSTEIN, BA ;
CRAWFORD, ED ;
MONTIE, JE ;
SCARDINO, P ;
GROSSMAN, HB ;
STANISIC, TH ;
SMITH, JA ;
SULLIVAN, J ;
SAROSDY, MF ;
CRISSMAN, JD ;
COLTMAN, CA .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (17) :1205-1209
[5]  
MCKIERNAN J, 2009, 5 INT M REPL ONC VIR
[6]   Treatment options for BCG failures [J].
O'Donnell, Michael A. ;
Boehle, Andreas .
WORLD JOURNAL OF UROLOGY, 2006, 24 (05) :481-487
[7]   Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer:: A phase I study of p53 gene therapy [J].
Pagliaro, LC ;
Keyhani, A ;
Williams, D ;
Woods, D ;
Liu, BS ;
Perrotte, P ;
Slaton, JW ;
Merritt, JA ;
Grossman, HB ;
Dinney, CP .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (12) :2247-2253
[8]   Efficacy and safety of valrubicin for the treatment of bacillus Calmette-Guerin refractory carcinoma in situ of the bladder [J].
Steinberg, G ;
Bahnson, R ;
Brosman, S ;
Middleton, R ;
Wajsman, Z ;
Wehle, M .
JOURNAL OF UROLOGY, 2000, 163 (03) :761-767
1