Standard fortification of preterm human milk fails to meet recommended protein intake: Bedside evaluation by Near-Infrared-Reflectance-Analysis

被引：42
作者：
Corvaglia, Luigi [1 ,2 ]
Aceti, Arianna [1 ]
Paoletti, Vittoria [1 ]
Mariani, Elisa [1 ]
Patrono, Daniela [3 ]
Ancora, Gina [1 ]
Capretti, Maria Grazia [1 ]
Faidella, Giacomo [1 ,2 ]
机构：
[1] Univ Bologna, S Orsola Malpighi Hosp, Neonatol & Neonatal Intens Care Unit, I-40126 Bologna, Italy
[2] Univ Bologna, CIRAU, I-40126 Bologna, Italy
[3] St Orsola Marcello Malpighi Hosp, Cent Lab, Bologna, Italy
来源：
EARLY HUMAN DEVELOPMENT | 2010年 / 86卷 / 04期
关键词：
Human milk fortification; Human milk protein content; Near-Infrared-Reflectance-Analysis; Osmolality; Preterm infant; INFANTS; NUTRITION; NITROGEN;
D O I：
10.1016/j.earlhumdev.2010.04.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Protein content of preterm human milk (HM) is relatively low and extremely variable among mothers: thus, recommended protein intake is rarely met. Objectives: To evaluate in a NICU setting if HM protein content after standard fortification meets the recommended intake, and also to check the effect of fortification on the osmolality of HM, as an index of feeding intolerance. Methods: Protein content of 34 preterm HM samples was evaluated by a bedside technique (Near-Infrared-Reflectance-Analysis - NIRA); osmolality was also checked. Seventeen samples were fortified with Aptamil BMF, Milupa (Group A) and 17 with FM85, Nestle (Group 13). Fortification was performed as recommended by the manufacturer ("full fortification [FF]") and also with a lower amount of fortifier ("low-dose fortification [LF]"). After fortification, actual protein content was calculated and compared to that needed to meet recommended intake (2.33-3 g/dl), and osmolality was measured. Results: After FF, protein content was above 3 g/dl in none of the samples, and below 233 g/dl in 16/34 samples (11 in Group A, 5 in Group B). After LF, protein content was above 3 g/dl in none of the samples and below 233 g/dl in 32/34 samples (15 in Group A, 17 in Group B). Osmolality exceeded 400 mOsm/kg in 19 samples after FF (10 in Group A, 9 in Group B) and in 2/34 samples after LF (1 in each group). Conclusion: HM protein content after standard fortification fails to meet the recommended intake for preterm infants in approximately half of the cases. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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页码：237 / 240
页数：4
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