Inhibiting the assembly of protein protein interfaces

被引：94
作者：
Zutshi, R [1 ]
Brickner, M [1 ]
Chmielewski, J [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(98)80036-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein-protein association is found throughout mechanisms of cellular growth and differentiation, and viral replication. Inhibiting the assembly of protein complexes, therefore, presents itself as a novel means of inhibition for a wide:variety of cellular and viral events. Peptides and small molecules that modify the overall quaternary structure of a selection of receptor-ligand interactions and oligomeric viral enzymes have been developed recently.
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收藏
页码：62 / 66
页数：5
相关论文
共 31 条
[1]   INHIBITION OF HIV PROTEASE ACTIVITY BY HETERODIMER FORMATION [J].
BABE, LM ;
PICHUANTES, S ;
CRAIK, CS .
BIOCHEMISTRY, 1991, 30 (01) :106-111
[2]   THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].
BENEZRA, R ;
DAVIS, RL ;
LOCKSHON, D ;
TURNER, DL ;
WEINTRAUB, H .
CELL, 1990, 61 (01) :49-59
[3]   The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the F185H mutant [J].
Bujacz, G ;
Alexandratos, J ;
ZhouLiu, Q ;
ClementMella, C ;
Wlodawer, A .
FEBS LETTERS, 1996, 398 (2-3) :175-178
[4]   HIV-1 protease inhibitors - A review for clinicians [J].
Deeks, SG ;
Smith, M ;
Holodniy, M ;
Kahn, JO .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (02) :145-153
[5]   SPECIFIC-INHIBITION OF HERPES-SIMPLEX VIRUS-DNA POLYMERASE BY HELICAL PEPTIDES CORRESPONDING TO THE SUBUNIT INTERFACE [J].
DIGARD, P ;
WILLIAMS, KP ;
HENSLEY, P ;
BROOKS, IS ;
DAHL, CE ;
COEN, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1456-1460
[6]   THE EXTREME-C TERMINUS OF HERPES-SIMPLEX VIRUS-DNA POLYMERASE IS CRUCIAL FOR FUNCTIONAL INTERACTION WITH PROCESSIVITY FACTOR-UL42 AND FOR VIRAL REPLICATION [J].
DIGARD, P ;
BEBRIN, WR ;
WEISSHART, K ;
COEN, DM .
JOURNAL OF VIROLOGY, 1993, 67 (01) :398-406
[7]  
DIVITA G, 1994, J BIOL CHEM, V269, P13080
[8]  
FILATOV D, 1992, J BIOL CHEM, V267, P15816
[9]   PROTEIN-PROTEIN INTERACTION AND ENZYMATIC ACTIVITY [J].
FRIEDEN, C .
ANNUAL REVIEW OF BIOCHEMISTRY, 1971, 40 :653-+
[10]   RATIONAL DESIGN OF POTENT ANTAGONISTS TO THE HUMAN GROWTH-HORMONE RECEPTOR [J].
FUH, G ;
CUNNINGHAM, BC ;
FUKUNAGA, R ;
NAGATA, S ;
GOEDDEL, DV ;
WELLS, JA .
SCIENCE, 1992, 256 (5064) :1677-1680
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