Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

被引：159

作者：

Abrams, Rachel P. ^{[1
,2
]}

Carroll, William L. ^{[2
]}

Woerpel, K. A. ^{[1
]}

机构：

[1] NYU, Dept Chem, 100 Washington Sq East, New York, NY 10003 USA

[2] NYU, Langone Med Ctr, Laura & Isaac Perlmutter Canc Ctr, 522 First Ave, New York, NY 10016 USA

来源：

ACS CHEMICAL BIOLOGY | 2016年 / 11卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DEATH; APOPTOSIS; LINE; IRON; MECHANISMS; CLASSIFICATION; STATISTICS; ACTIVATION; RESISTANCE; EXPRESSION;

D O I：

10.1021/acschembio.5b00900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 degrees C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.

引用

页码：1305 / 1312

页数：8

共 69 条

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