Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

被引：166

作者：

Abrams, Rachel P. ^{[1
,2
]}

Carroll, William L. ^{[2
]}

Woerpel, K. A. ^{[1
]}

机构：

[1] NYU, Dept Chem, 100 Washington Sq East, New York, NY 10003 USA

[2] NYU, Langone Med Ctr, Laura & Isaac Perlmutter Canc Ctr, 522 First Ave, New York, NY 10016 USA

来源：

ACS CHEMICAL BIOLOGY | 2016年 / 11卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DEATH; APOPTOSIS; LINE; IRON; MECHANISMS; CLASSIFICATION; STATISTICS; ACTIVATION; RESISTANCE; EXPRESSION;

D O I：

10.1021/acschembio.5b00900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 degrees C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.

引用

页码：1305 / 1312

页数：8

共 69 条

[1] Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings [J].

Abdel-Fatah, T. M. A. ;

Perry, C. ;

Dickinson, P. ;

Ball, G. ;

Moseley, P. ;

Madhusudan, S. ;

Ellis, I. O. ;

Chan, S. Y. T. .

ANNALS OF ONCOLOGY, 2013, 24 (11) :2801-2807

[2] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice [J].

Angeli, Jose Pedro Friedmann ;

Schneider, Manuela ;

Proneth, Bettina ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Hammond, Victoria J. ;

Herbach, Nadja ;

Aichler, Michaela ;

Walch, Axel ;

Eggenhofer, Elke ;

Basavarajappa, Devaraj ;

Radmark, Olof ;

Kobayashi, Sho ;

Seibt, Tobias ;

Beck, Heike ;

Neff, Frauke ;

Esposito, Irene ;

Wanke, Ruediger ;

Foerster, Heidi ;

Yefremova, Olena ;

Heinrichmeyer, Marc ;

Bornkamm, Georg W. ;

Geissler, Edward K. ;

Thomas, Stephen B. ;

Stockwell, Brent R. ;

O'Donnell, Valerie B. ;

Kagan, Valerian E. ;

Schick, Joel A. ;

Conrad, Marcus .

NATURE CELL BIOLOGY, 2014, 16 (12) :1180-U120

[3]

[Anonymous], 2010, GUID TREATM MAL, DOI DOI 10.1080/03630269.2023.2168201

[4] New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays [J].

Baell, Jonathan B. ;

Holloway, Georgina A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (07) :2719-2740

[5] Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells [J].

Berdelle, Nicole ;

Nikolova, Teodora ;

Quiros, Steve ;

Efferth, Thomas ;

Kaina, Bernd .

MOLECULAR CANCER THERAPEUTICS, 2011, 10 (12) :2224-2233

[6] Analysis of p53 mutation status in human cancer cell lines - A paradigm for cell line cross-contamination [J].

Berglind, Hanna ;

Pawitan, Yudi ;

Kato, Shunsuke ;

Ishioka, Chikashi ;

Soussi, Thierry .

CANCER BIOLOGY & THERAPY, 2008, 7 (05) :699-708

[7] Glutathione peroxidases [J].

Brigelius-Flohe, Regina ;

Maiorino, Matilde .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 1830 (05) :3289-3303

[8] Rules for Identifying Potentially Reactive or Promiscuous Compounds [J].

Bruns, Robert F. ;

Watson, Ian A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (22) :9763-9772

[9] Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-κB [J].

Chen, Hua ;

Sun, Bei ;

Wang, Shuangjia ;

Pan, Shangha ;

Gao, Yue ;

Bai, Xuewei ;

Xue, Dongbo .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2010, 136 (06) :897-903

[10] Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy [J].

Chonghaile, Triona Ni ;

Sarosiek, Kristopher A. ;

Thanh-Trang Vo ;

Ryan, Jeremy A. ;

Tammareddi, Anupama ;

Moore, Victoria Del Gaizo ;

Deng, Jing ;

Anderson, Kenneth C. ;

Richardson, Paul ;

Tai, Yu-Tzu ;

Mitsiades, Constantine S. ;

Matulonis, Ursula A. ;

Drapkin, Ronny ;

Stone, Richard ;

DeAngelo, Daniel J. ;

McConkey, David J. ;

Sallan, Stephen E. ;

Silverman, Lewis ;

Hirsch, Michelle S. ;

Carrasco, Daniel Ruben ;

Letai, Anthony .

SCIENCE, 2011, 334 (6059) :1129-1133

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