Wnt signaling in development and disease

被引：158
作者：
Freese, Jennifer L.
Pino, Darya
Pleasure, Samuel J. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, Program Neurosci, San Francisco, CA 94143 USA
来源：
NEUROBIOLOGY OF DISEASE | 2010年 / 38卷 / 02期
关键词：
BETA-CATENIN; WILLIAMS-SYNDROME; WNT/BETA-CATENIN; AXON GUIDANCE; CORPUS-CALLOSUM; EMBRYONIC AXIS; RECEPTOR; DIFFERENTIATION; MICE; PATHWAY;
D O I：
10.1016/j.nbd.2009.09.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Wnt signaling pathway is one of the central morphogenic signaling pathways regulating early vertebrate development. In recent years, it has become clear that the Wnt pathway also regulates many aspects of nervous system development from the patterning stage through the regulation of neural plasticity. In this review, we first present an overview of the components of the Wnt signaling pathway and then go on to discuss the literature describing the multitude of roles of Wnts in nervous system. In the latter portion of the review, we turn to the ways that defects in Wnt signaling lead to neurologic disease. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：148 / 153
页数：6
相关论文
共 76 条
[21]   Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling [J].
Hall, AC ;
Lucas, FR ;
Salinas, PC .
CELL, 2000, 100 (05) :525-535
[22]   Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure [J].
Hamblet, NS ;
Lijam, N ;
Ruiz-Lozano, P ;
Wang, JB ;
Yang, YS ;
Luo, ZG ;
Mei, L ;
Chien, KR ;
Sussman, DJ ;
Wynshaw-Boris, A .
DEVELOPMENT, 2002, 129 (24) :5827-5838
[23]   LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:: Arrows point the way [J].
He, X ;
Semenov, M ;
Tamai, K ;
Zeng, X .
DEVELOPMENT, 2004, 131 (08) :1663-1677
[24]   Wnt/β-catenin signaling:: new (and old) players and new insights [J].
Huang, He ;
He, Xi .
CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (02) :119-125
[25]   Ryk: A novel Wnt receptor regulating axon pathfinding [J].
Keeble, Thomas R. ;
Cooper, Helen M. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (12) :2011-2017
[26]   The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum [J].
Keeble, Thomas R. ;
Halford, Michael M. ;
Seaman, Clare ;
Kee, Nigel ;
Macheda, Maria ;
Anderson, Richard B. ;
Stacker, Steven A. ;
Cooper, Helen M. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (21) :5840-5848
[27]   Repressor activity of headless/Tcf3 is essential for vertebrate head formation [J].
Kim, CH ;
Oda, T ;
Itoh, M ;
Jiang, D ;
Artinger, KB ;
Chandrasekharappa, SC ;
Driever, W ;
Chitnis, AB .
NATURE, 2000, 407 (6806) :913-916
[28]   Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors [J].
Koch, A ;
Waha, A ;
Tonn, JC ;
Sörensen, N ;
Berthold, F ;
Wolter, M ;
Reifenberger, J ;
Hartmann, W ;
Friedl, W ;
Reifenberger, G ;
Wiestler, OD ;
Pietsch, T .
INTERNATIONAL JOURNAL OF CANCER, 2001, 93 (03) :445-449
[29]   Wnt and calcium signaling:: β-Catenin-independent pathways [J].
Kohn, AD ;
Moon, RT .
CELL CALCIUM, 2005, 38 (3-4) :439-446
[30]   Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis [J].
Kokubu, C ;
Heinzmann, U ;
Kokubu, T ;
Sakai, N ;
Kubota, T ;
Kawai, M ;
Wahl, MB ;
Galceran, J ;
Grosschedl, R ;
Ozono, K ;
Imai, K .
DEVELOPMENT, 2004, 131 (21) :5469-5480
12345678