Wnt signaling in development and disease

被引：158
作者：
Freese, Jennifer L.
Pino, Darya
Pleasure, Samuel J. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, Program Neurosci, San Francisco, CA 94143 USA
来源：
NEUROBIOLOGY OF DISEASE | 2010年 / 38卷 / 02期
关键词：
BETA-CATENIN; WILLIAMS-SYNDROME; WNT/BETA-CATENIN; AXON GUIDANCE; CORPUS-CALLOSUM; EMBRYONIC AXIS; RECEPTOR; DIFFERENTIATION; MICE; PATHWAY;
D O I：
10.1016/j.nbd.2009.09.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Wnt signaling pathway is one of the central morphogenic signaling pathways regulating early vertebrate development. In recent years, it has become clear that the Wnt pathway also regulates many aspects of nervous system development from the patterning stage through the regulation of neural plasticity. In this review, we first present an overview of the components of the Wnt signaling pathway and then go on to discuss the literature describing the multitude of roles of Wnts in nervous system. In the latter portion of the review, we turn to the ways that defects in Wnt signaling lead to neurologic disease. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：148 / 153
页数：6
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