Interfacing the orbitrap mass analyzer to an electrospray ion source

被引:194
作者
Hardman, M [1 ]
Makarov, AA [1 ]
机构
[1] Thermo Masslab Ltd, Manchester M23 9BE, Lancs, England
关键词
D O I
10.1021/ac0258047
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The orbitrap mass analyzer employs the trapping of pulsed ion beams in an electrostatic quadro-logarithmic field. This field is created between an axial central electrode and a coaxial outer electrode. Stable ion trajectories combine rotation around the central electrode with harmonic oscillations along it. The frequencies of axial oscillations and hence mass-to-charge ratios of ions are obtained using fast Fourier transform of the image current detected on the two split halves of the outer electrode. This work proves that such a trap could be coupled to a continuous, electrospray, ion source. Such a coupling necessitated the development of an rf-only quadrupole for external accumulation of ions and their injection in very short (< 1 mus) ion bunches. Along with good sensitivity, this mass spectrometer provides mass resolving power up to 150000 fvhm, mass accuracies within a few parts per million, and relative mass range up to 8-fold. The maximum number of ions available for analysis is limited by the space-charge capacity of the accumulation quadrupole.
引用
收藏
页码:1699 / 1705
页数:7
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