LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes

被引：36
作者：
He, Jingjing [1 ]
Yang, Kang [1 ]
Zhao, Jianhong [1 ]
Cao, Song [1 ]
机构：
[1] ECUST, Sch Pharm, Shanghai 200237, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 23期
关键词：
C-F BOND; GENERATED IN-SITU; VERSATILE CATALYST; ACTIVATION; COMPLEXES; LIGAND; FUNCTIONALIZATION; REACTIVITY; MECHANISM; DBA;
D O I：
10.1021/acs.orglett.9b03815
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient Pd-catalyzed Sonogashira coupling of various aryl fluorides with terminal alkynes in the presence of LiHMDS was developed. Both unreactive electron-rich fluoroarenes and electron-poor fluoroarenes proceeded smoothly and afforded the corresponding internal alkynes in moderate to excellent yields.
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收藏
页码：9714 / 9718
页数：5
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