Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis

被引:53
作者
Dibaba, D. T. [1 ]
Xun, P. [1 ]
Fly, A. D. [2 ]
Yokota, K. [3 ]
He, K. [1 ]
机构
[1] Indiana Univ, Dept Epidemiol & Biostat, Sch Publ Hlth Bloomington, Bloomington, IN 47405 USA
[2] Indiana Univ, Dept Appl Hlth Sci, Sch Publ Hlth Bloomington, Bloomington, IN 47405 USA
[3] Jikei Univ, Sch Med, Dept Internal Med, Tokyo, Japan
基金
美国国家卫生研究院;
关键词
CORONARY-HEART-DISEASE; LIFE-STYLE FACTORS; DOUBLE-BLIND; NONDIABETIC SUBJECTS; INSULIN SENSITIVITY; SMOOTH-MUSCLE; FATTY-ACIDS; ADULTS; SUPPLEMENTATION; ASSOCIATION;
D O I
10.1111/dme.12537
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimsTo estimate quantitatively the association between dietary magnesium intake and risk of metabolic syndrome by combining the relevant published articles using meta-analysis. MethodsWe reviewed the relevant literature in PubMed and EMBASE published up until August 2013 and obtained additional information through Google or a hand search of the references in relevant articles. A random-effects or fixed-effects model, as appropriate, was used to pool the effect sizes on metabolic syndrome comparing individuals with the highest dietary magnesium intake with those having the lowest intake. The dose-response relationship was assessed for every 100-mg/day increment in magnesium intake and risk of metabolic syndrome. ResultSix cross-sectional studies, including a total of 24 473 individuals and 6311 cases of metabolic syndrome, were identified as eligible for the meta-analysis. A weighted inverse association was found between dietary magnesium intake and the risk of metabolic syndrome (odds ratio 0.69, 95% CI 0.59, 0.81) comparing the highest with the lowest group. For every 100-mg/day increment in magnesium intake, the overall risk of having metabolic syndrome was lowered by 17% (odds ratio 0.83, 95% CI 0. 77, 0.89). ConclusionFindings from the present meta-analysis suggest that dietary magnesium intake is inversely associated with the prevalence of metabolic syndrome. Further studies, in particular well-designed longitudinal cohort studies and randomized placebo-controlled clinical trials, are warranted to provide solid evidence and to establish causal inference.
引用
收藏
页码:1301 / 1309
页数:9
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