Systemic Epstein-Barr Virus-Positive T-cell Lymphoma of Childhood

We report a case of a 7-year-old Chinese boy who presented with acute fever, multiple oral ulcers, and skin nodules. A diagnosis of systemic Epstein-Barr virus (EBV)- positive T-cell lymphoma of childhood was established using systemic laboratory examination,imaging studies, bone marrow and skin biopsy with immunohisto-chemistry,and in situ hybridization for EBV-encoded RNA (EBER)and gene rearrangements. Notable features of this case include the absence of pancytopenia and hemophagocytic syndrome as well as spontaneous resolution without chemotherapy for several months;however, the condition relapsed, and the patient died.