Risk Factors and Time to Occurrence of Genitourinary Toxicity After External Beam Radiotherapy for Prostate Cancer

被引：0
作者：
Kanemoto, Ayae [1 ]
Matsumoto, Yasuo [1 ]
Sugita, Tadashi [1 ]
Abe, Eisuke [3 ]
Yamana, Nobuko [3 ]
Saito, Toshihiro [2 ]
Kobayashi, Kazuhiro [2 ]
Yamazaki, Hiroyuki [2 ]
Bilim, Vladimir [2 ]
Tanikawa, Toshiki [2 ]
机构：
[1] Niigata Canc Ctr Hosp, Dept Radiat Oncol, 2-15-3 Kawagishi Cho, Niigata 9518566, Japan
[2] Niigata Canc Ctr Hosp, Dept Urol, 2-15-3 Kawagishi Cho, Niigata 9518566, Japan
[3] Niigata Univ, Med & Dent Hosp, Dept Radiat Oncol, Niigata, Japan
来源：
ANTICANCER RESEARCH | 2016年 / 36卷 / 05期
关键词：
Genitourinary toxicity; timing; risk factor; external-beam radiotherapy; prostate cancer; CONFORMAL RADIOTHERAPY; HORMONAL-THERAPY; DOSE-ESCALATION; TRIAL; OUTCOMES;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To retrospectively investigate the risk factors and time to occurrence of genitourinary (GU) toxicity after radiotherapy for localized prostate cancer. Patients and Methods: The study included 320 patients. The radiotherapy planning target volume encompassed the prostate with a 1-cm margin in the transverse plane and a 1-cm margin (Group A) or a 1.5-cm margin (Group B) in the longitudinal plane. Incidence rates, risk factors and time to occurrence of GU toxicity were evaluated. Results: After a median follow-up of 38.2 months, the rate of late grade 2-3 GU toxicity was 5.9% and the median interval was 18.3 months. The wider longitudinal margin was the single significant independent factor. The 2-year cumulative incidence rates of late grade >= 2 GU toxicity were 2.8% and 7.5% in Group A and B patients. Conclusion: A wider radiotherapy margin increased the risk of GU toxicity and led to earlier occurrence.
引用
收藏
页码：2441 / 2444
页数：4
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